2026-10-15T02:17:16Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/97562024-12-05T01:05:13Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597
Repositorio Institucional de la Universidad de Burgos
author
Jiménez Pérez, Alondra
author
Martínez Alonso, Marta
author
García Tojal, Javier
2024-12-04T12:47:03Z
2024-12-04T12:47:03Z
2024-09
http://hdl.handle.net/10259/9756
10.3390/molecules29184479
1420-3049
Calcium phosphates (CaPs) and their substituted derivatives encompass a large number of compounds with a vast presence in nature that have aroused a great interest for decades. In particular, hydroxyapatite (HAp, Ca10(OH)2(PO4)6) is the most abundant CaP mineral and is significant in the biological world, at least in part due to being a major compound in bones and teeth. HAp exhibits excellent properties, such as safety, stability, hardness, biocompatibility, and osteoconductivity, among others. Even some of its drawbacks, such as its fragility, can be redirected thanks to another essential feature: its great versatility. This is based on the compound’s tendency to undergo substitutions of its constituent ions and to incorporate or anchor new molecules on its surface and pores. Thus, its affinity for biomolecules makes it an optimal compound for multiple applications, mainly, but not only, in biological and biomedical fields. The present review provides a chemical and structural context to explain the affinity of HAp for biomolecules such as proteins and nucleic acids to generate hybrid materials. A size-dependent criterium of increasing complexity is applied, ranging from amino acids/nucleobases to the corresponding macromolecules. The incorporation of metal ions or metal complexes into these functionalized compounds is also discussed.
eng
Atribución 4.0 Internacional
Amino acid
Calcium phosphate
Hybrid material
Nucleobase
Hydroxyapatite
Nucleic acid
Peptide
Protein
Hybrid Hydroxyapatite–Metal Complex Materials Derived from Amino Acids and Nucleobases
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/9756/1/Jimenez-molecules_2024.pdf
File
MD5
1241aa8d6b237c6e5046850333a733b1
1752733
application/pdf
Jimenez-molecules_2024.pdf