2026-05-30T04:53:19Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/97572024-12-26T23:42:12Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597

00925njm 22002777a 4500 dc Jiménez Pérez, Alondra author Fernández-Fariña, Sandra author Pedrido Castiñeiras, Rosa author García Tojal, Javier author 2023-12 Thiosemicarbazones are biologically active substances whose structural formula is formed by an azomethine, an hydrazine, and a thioamide fragments, to generate a R2C=N–NR–C(=S)–NR2 backbone. These compounds often act as ligands to generate highly stable metal–organic complexes. In certain experimental conditions, however, thiosemicarbazones undergo reactions leading to the cleavage of the chain. Sometimes, the breakage involves desulfurization processes. The present work summarizes the different chemical factors that influence the desulfurization reactions of thiosemicarbazones, such as pH, the presence of oxidant reactants or the establishment of redox processes as those electrochemically induced, the effects of the solvent, the temperature, and the electromagnetic radiation. Many of these reactions require coordination of thiosemicarbazones to metal ions, even those present in the intracellular environment. The nature of the products generated in these reactions, their detection in vivo and in vitro, together with the relevance for the biological activity of these compounds, mainly as antineoplastic agents, is discussed. http://hdl.handle.net/10259/9757 10.1007/s00775-023-02037-7 1432-1327 Antitumor Biological activity Cyclization Desulfurization Metal complexes Thiosemicarbazone Desulfurization of thiosemicarbazones: the role of metal ions and biological implications