2026-06-19T16:55:20Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/98072024-12-20T01:05:28Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597
Repositorio Institucional de la Universidad de Burgos
author
Burgos López, Y.
author
Balsa, Lucía M.
author
Piro, Oscar Enrique
author
León, Ignacio E.
author
García Tojal, Javier
author
Echeverría, Gustavo A.
author
González Baró, Ana C.
author
Parajón Costa, Beatriz S.
2024-12-18T12:06:39Z
2024-12-18T12:06:39Z
2022-02
0277-5387
http://hdl.handle.net/10259/9807
10.1016/j.poly.2021.115621
Two new penta-coordinated copper(II) hydrazone coordination compounds with 2,2́ bipyridine (I) or 1,10 phenanthroline (II) as coligands are synthesized and characterized in the solid state and in solution by spectroscopic methods (FTIR, Raman, UV–vis, EPR). Single crystal X-ray studies show that they have closely related molecular structures with the copper center in a distorted square pyramidal O2N3 environment. The N-acylhydrazone, 4-hydroxy-NŃ-(E)2-hydroxy-3-methoxybenzylidene]benzohydrazide, H2L, coordinates tridentate through its ONO donor atoms as monoanion (HL-) in the cationic complex (I), [Cu(HL)(bipy)](NO3). During the period that takes the synthesis reaction of compound (II), [Cu(L)(o-phen)] to complete, keto-amine to enol-imine tautomerization of H2L occurs and the hydrazone coordinates tridentate as dianionic ligand (L2-). The fivefold coordination sphere of the complexes is completed with the nitrogen atoms of the respective coligands. Cytotoxicity studies against bone (MG-63, IC50(I) = 5.6 ± 1.0 , IC50(II) = 3.5 ± 0.3), breast (MCF7, IC50(I) = 10.8 ± 1.9, IC50(II) = 4.0 ± 1.3), (MDA-MB-231, IC50(I) = 11.4 ± 0.6, IC50(II) = 5.3 ± 0.2) and lung cancer cells (A549, IC50(I) = 7.7 ± 0.7, IC50(II) = 7.0 ± 0.4) reveals increased effectiveness of both complexes compared with the free ligand, the copper nitrate salt and the reference metallodrug cisplatin (CDDP).
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Cu(II)-complexes
Hydrazones
Spectroscopy
Crystal structure
Anticancer activity
Tridentate acylhydrazone copper(II) complexes with heterocyclic bases as coligands. Synthesis, spectroscopic studies, crystal structure and cytotoxicity assays
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/9807/5/Burgos-polyhedron_2022.pdf
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Burgos-polyhedron_2022.pdf