2026-11-01T17:49:56Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/98972025-01-15T01:05:25Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

Biosca-Brull, Judit Pérez Fernández, Cristian Mora, Santiago Carrillo, Beatriz Pinos, Helena Conejo, Nelida Maria Collado, Paloma Arias, Jorge L. Martín-Sánchez, Fernando Sánchez Santed, Fernando Colomina, María Teresa 2025-01-14T09:33:38Z 2025-01-14T09:33:38Z 2021-05 1660-4601 http://hdl.handle.net/10259/9897 10.3390/ijerph18105190 1660-4601 Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies. he study was supported by grants from the Spanish Goverment (Ministerio de Economía y Competitividad, Ministerio de Ciencia, Innovación y Universidades and Instituto Mixto de Investigación-Escuela Nacional de Sanidad (IMIENS)) and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER) [Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER, PSI2017-86847-C2-2-R, PSI2017-86396-P, PSI2017-90806-REDT, PSI2013-45924-P, PSI2017-83038-P, PSI2017-83893-R, MINECO PSI2017-86396-P and IMIENS: PIC-IMIENS-2018-003]. application/pdf eng MDPI International Journal of Environmental Research and Public Health. 2021, V.18, n. 10, 5190 https://doi.org/10.3390/ijerph18105190 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2017-86847-C2-1-R/ES/CORRELATOS NEURO-BIOLOGICOS DE LOS DESORDENES DEL NEURODESARROLLO INDUCIDOS POR FACTORES GENETICOS O AMBIENTALES/ Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Autism spectrum disorder Sociability Pesticide Organophosphate Carbamates Organochlorine Chlorpyrifos Trastornos del espectro autista Pesticidas Autism spectrum disorders Pesticides Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion International Journal of Environmental Research and Public Health 18 10 5190