2026-09-06T16:59:26Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/98972025-01-15T01:05:25Zcom_10259_9895com_10259_3989com_10259.4_106com_10259_2604col_10259_9896

Biosca-Brull, Judit e8f5abab-7b22-4ed3-aae2-f00f56f45d3b 500 Pérez Fernández, Cristian 41151d83-48a8-4363-a23a-b2cf33d3d481 600 Mora, Santiago 0366d3b1-0580-43e8-82fe-d9bf3922c64d 500 Carrillo, Beatriz e0d4ab27-3533-4895-9c3f-96815163895f 500 Pinos, Helena 4076bc32-7aa0-4017-b916-899aab3fc634 500 Conejo, Nelida Maria ddaf545b-d2c1-455d-be12-62a50512c6f9 500 Collado, Paloma c6d22bea-d373-4feb-919b-8bb3331abdcd 500 Arias, Jorge L. 84a24844-5d04-410b-8ff4-3e69bd2fed61 500 Martín-Sánchez, Fernando 57ee57bb-6bdf-4137-b3ed-048f4b3f62f5 500 Sánchez Santed, Fernando 3945434c-d67b-4d35-8c6d-262ce027f039 600 Colomina, María Teresa b33a2d2e-b902-4a99-809f-551a9af83d1c 600 2025-01-14T09:33:38Z 2025-01-14T09:33:38Z 2021-05 1660-4601 http://hdl.handle.net/10259/9897 10.3390/ijerph18105190 1660-4601 Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies. he study was supported by grants from the Spanish Goverment (Ministerio de Economía y Competitividad, Ministerio de Ciencia, Innovación y Universidades and Instituto Mixto de Investigación-Escuela Nacional de Sanidad (IMIENS)) and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER) [Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER, PSI2017-86847-C2-2-R, PSI2017-86396-P, PSI2017-90806-REDT, PSI2013-45924-P, PSI2017-83038-P, PSI2017-83893-R, MINECO PSI2017-86396-P and IMIENS: PIC-IMIENS-2018-003]. application/pdf eng MDPI International Journal of Environmental Research and Public Health. 2021, V.18, n. 10, 5190 https://doi.org/10.3390/ijerph18105190 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2017-86847-C2-1-R/ES/CORRELATOS NEURO-BIOLOGICOS DE LOS DESORDENES DEL NEURODESARROLLO INDUCIDOS POR FACTORES GENETICOS O AMBIENTALES/ Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Autism spectrum disorder Sociability Pesticide Organophosphate Carbamates Organochlorine Chlorpyrifos Trastornos del espectro autista Pesticidas Autism spectrum disorders Pesticides Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion International Journal of Environmental Research and Public Health 18 10 5190 THUMBNAIL Biosca-ijerph_2021.pdf.jpg Biosca-ijerph_2021.pdf.jpg IM Thumbnail image/jpeg 3560 https://riubu.ubu.es/bitstream/10259/9897/4/Biosca-ijerph_2021.pdf.jpg f0cc29224e074c3f7e51a3aecbd14dc5 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/9897/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/9897/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Biosca-ijerph_2021.pdf Biosca-ijerph_2021.pdf application/pdf 608382 https://riubu.ubu.es/bitstream/10259/9897/1/Biosca-ijerph_2021.pdf 850b0b8f59bc2377cc0d30ca0dcedae5 MD5 1 10259/9897 oai:riubu.ubu.es:10259/9897 2025-01-15 02:05:25.23 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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