2024-03-29T11:51:44Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/52422021-11-02T12:06:21Zcom_10259_4725com_10259_5086com_10259_2604col_10259_4726
2020-03-13T09:13:36Z
urn:hdl:10259/5242
Intestinal fructose and glucose metabolism in health and disease
Perdomo Hernández, Germán M.
Merino, Beatriz
Fernández Díaz, Cristina M. .
Cózar Castellano, Irene
fructose
glucose
small intestine
liver
brain
gut-brain axis
non-alcoholic fatty liver
insulin resistance
metabolic syndrome
type 2 diabetes mellitus
The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed.
2020-03-13T09:13:36Z
2020-03-13T09:13:36Z
2020-01
info:eu-repo/semantics/article
http://hdl.handle.net/10259/5242
10.3390/nu12010094
2072-6643
eng
Nutrients. 2020, V. 12, n. 1, 94
https://doi.org/10.3390/nu12010094
info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-1-R
info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-2-R
info:eu-repo/grantAgreement/FundaciónLaCaixa/CAIXA-UBU001
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
MDPI