2024-03-29T07:41:29Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/42812022-04-29T12:02:48Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594
Feberero, Claudia
Velasco, Rocío
Sanz Díez, Roberto
2016-11-24T08:10:48Z
2017-11-01T03:45:07Z
2016-11
1434-193X
http://hdl.handle.net/10259/4281
New dihalosalicylamides and trihalophenol derivatives have been synthesized from easily available O-(3,n-dihalophenyl) N,N-diethylcarbamates by using a directed ortho-metalation (DoM) strategy. The o-lithiation reactions with sBuLi take place regioselectively at the doubly activated C-2 position, which demonstrates the ability of O-carbamates as directed metalating groups. In addition, highly functionalized arylnitriles were accessed from organolithium intermediates by using a tandem transnitrilation/SNAr reaction sequence.
Junta de Castilla y León (Consejería de
Educación) and FEDER (BU237U13 and BU076U16) as well as
the Ministerio de Economía y Competitividad (MINECO) and
FEDER (CTQ2013-48937-C2-1-P)
application/pdf
spa
Wiley-VCH Verlag
European Journal of Organic Chemistry. 2016, n. 33, p. 5445–5587
http://dx.doi.org/10.1002/ejoc.201600933
Chemistry, Organic
Química orgánica
ortho-Lithiation Reactions of O-(3,n-Dihalophenyl) N,N-Diethylcarbamates: Synthesis of Dihalosalicylamides and 2,3,n-Trihalophenol Derivatives
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
info:eu-repo/semantics/openAccess