2024-03-29T06:58:54Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/42572021-11-10T09:38:26Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250
Determination of dichlobenil and its major metabolite (BAM) in onions by PTV–GC–MS using PARAFAC2 and experimental design methodology
Herrero Gutiérrez, Ana
Reguera Alonso, Celia
Ortiz Fernández, Mª Cruz
Sarabia Peinador, Luis Antonio
PTV–GC–MS
D-optimal design
Parallel factor analysis
Desirability function
Dichlobenil
SANCO/12495/2001
Química analítica
Chemistry, Analytic
The optimization of a GC–MS analytical procedure which includes derivatization, Quick Easy Cheap Effective Rugged and Safe (QuEChERS) and programmed temperature vaporization (PTV) using design of experiments is performed to determine 2,6-dichlorobenzonitrile (dichlobenil) and 2,6-dichlorobenzamide (BAM) in onions, using 3,5-dichlorobenzonitrile and 2,4-dichlorobenzamide as internal standards. The use of a central composite design and two D-optimal designs, together with the desirability function, makes it possible to significantly reduce the economic, time and environmental cost of the study. The usefulness of PARAFAC2 for solving problems as the interference of unexpected derivatization artifacts unavoidably linked to some derivatization agents, or the presence of coeluents from the complex matrix, which share m/z ratios with the target compounds, is shown. The limits of decision (CCα) of the optimized procedure, 5.00 μg kg− 1 for dichlobenil and 1.55 μg kg− 1 for BAM (α = 0.05), are below the maximum residue limit (MRL) established by the EU for dichlobenil (20 μg kg− 1) in this commodity.
Ministerio de Economía y Competitividad (CTQ2011-26022) and Junta
de Castilla y León (BU108A11-2)
2016-10-19T11:28:07Z
2016-10-19T11:28:07Z
2014-04
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
0169-7439
http://hdl.handle.net/10259/4257
10.1016/j.chemolab.2013.12.001
eng
Chemometrics and intelligent laboratory systems. 2014, V. 133, p. 92–108
http://dx.doi.org/10.1016/j.chemolab.2013.12.001
info:eu-repo/grantAgreement/MINECO/CTQ2011-26022
info:eu-repo/grantAgreement/JCyL/BU108A11-2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
application/pdf
Elsevier
https://riubu.ubu.es/bitstream/10259/4257/7/Herrero-CILS_2014.pdf.jpg
Hispana
TEXT
http://creativecommons.org/licenses/by-nc-nd/4.0/
RIUBU. Repositorio Institucional de la Universidad de Burgos
http://hdl.handle.net/10259/4257