2024-03-28T13:52:02Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/52992022-04-06T13:11:39Zcom_10259_4292com_10259_5086com_10259_2604com_10259.4_2516col_10259_4293col_10259.4_2517
Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions
Gerardi, Gisela
Cavia Saiz, Mónica
Pino García, Raquel del
Rivero Pérez, Maria Dolores
González San José, Mª Luisa
Muñiz Rodríguez, Pilar
Aorta
Diabetes
Hypertension
Vascular remodeling
eNOS
Wine pomace product
Alimentos
Bioquímica
Biología molecular
Food
Biochemistry
Molecular biology
Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling.
Autonomous Government of Castilla y León (Research project BU282U13
2020-05-08T18:42:43Z
2020-05-08T18:42:43Z
2020-03
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
1756-4646
http://hdl.handle.net/10259/5299
10.1016/j.jff.2020.103794
eng
Journal of Functional Foods.2020, V. 66, 103794
https://doi.org/10.1016/j.jff.2020.103794
info:eu-repo/grantAgreement/JCyL/BU282U13
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
application/pdf
Elsevier
https://riubu.ubu.es/bitstream/10259/5299/4/Gerardi-jff_2020.pdf.jpg
Hispana
TEXT
http://creativecommons.org/licenses/by-nc-nd/4.0/
RIUBU. Repositorio Institucional de la Universidad de Burgos
http://hdl.handle.net/10259/5299