2024-03-29T14:58:09Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/42812022-04-29T12:02:48Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594
00925njm 22002777a 4500
dc
Feberero, Claudia
author
Velasco, Rocío
author
Sanz Díez, Roberto
author
2016-11
New dihalosalicylamides and trihalophenol derivatives have been synthesized from easily available O-(3,n-dihalophenyl) N,N-diethylcarbamates by using a directed ortho-metalation (DoM) strategy. The o-lithiation reactions with sBuLi take place regioselectively at the doubly activated C-2 position, which demonstrates the ability of O-carbamates as directed metalating groups. In addition, highly functionalized arylnitriles were accessed from organolithium intermediates by using a tandem transnitrilation/SNAr reaction sequence.
1434-193X
http://hdl.handle.net/10259/4281
ortho-Lithiation Reactions of O-(3,n-Dihalophenyl) N,N-Diethylcarbamates: Synthesis of Dihalosalicylamides and 2,3,n-Trihalophenol Derivatives