2024-03-28T09:26:28Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/60902022-12-02T01:05:49Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594
00925njm 22002777a 4500
dc
Martínez Lara, Fernando
author
Suárez, Anisley
author
Velasco Pérez, Noelia
author
Suarez Pantiga, Samuel
author
Sanz Díez, Roberto
author
2022-01
Propargylic glycols, 2-alkynyl-1-(indol-3-yl)-1,2-diols, react with thiols undergoing a complex but
selective gold-catalyzed transformation that gives rise to α-indol-3-yl α-((Z)-2-thioalkenyl) ketones. The
sequence is triggered by the regioselective thiolation of indolyl diols followed by an attack of the sulfur instead
of the indole over the activated alkyne. The final compounds are obtained in remarkably high yields and arise
from simple starting materials such as indolyl acyloins, ethynyl magnesium bromide and thiols.
1615-4169
http://hdl.handle.net/10259/6090
10.1002/adsc.202100930
Gold
Homogeneous catalysis
Nitrogen heterocycles
Rearrangement
Sulfur
Gold-Catalyzed Reactions of 2-Alkynyl-1-indolyl-1,2-diols with Thiols: Stereoselective Synthesis of (Z)-α-Indol-3-yl α-(2-Thioalkenyl) Ketones