2024-03-29T10:09:14Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/53212022-04-07T10:00:26Zcom_10259_4313com_10259_5086com_10259_2604col_10259_4314
Repositorio Institucional de la Universidad de Burgos
author
Guembe García, Marta
author
Peredo Guzmán, Patricia D.
author
Santaolalla García, Victoria
author
Moradillo Renuncio, Natalia
author
Ibeas Cortes, Saturnino
author
Mendía Jalón, Aránzazu
author
García García, Félix Clemente
author
García Pérez, José Miguel
author
Vallejos Calzada, Saúl
2020-06-03T08:52:19Z
2020-06-03T08:52:19Z
2020-06
http://hdl.handle.net/10259/5321
10.3390/polym12061249
2073-4360
We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and
a dye, to a polymer matrix obtaining film‐shaped chemosensors with induced selectivity toward
glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures
of amino acids mimicking elastin, collagen and epidermis, and also in following the protease activity
in a beefsteak and chronic human wounds. We use the term inducing because the probe in solution
is not selective toward any amino acid and we get selectivity toward glycine using the solid‐state.
Overall, we found that the chemical behaviour of a chemical probe can be entirely changed by
changing its chemical environment. Regarding its behaviour in solution, this change has been
achieved by isolating the probe by anchoring the motifs in a polymer matrix, in an amorphous state,
avoiding the interaction of one sensory motif with another. Moreover, this selectivity change can be
further tuned because of the effectiveness of the transport of targets both by the physical nature of
the interface of the polymer matrix/solution, where the target chemicals are dissolved, for instance,
and inside the matrix where the recognition takes place. The interest in chronic human wounds is
related to the fact that our methods are rapid and inexpensive, and also considering that the protease
activity can correlate with the evolution of chronic wounds.
eng
Atribución 4.0 Internacional
solid‐state chemosensors
sensory polymers
amino acids
chronic wounds
Why is the Sensory Response of Organic Probes within a Polymer Film Different in Solution and in the Solid-State? Evidence and Application to the Detection of Amino Acids in Human Chronic Wounds
info:eu-repo/semantics/article
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https://riubu.ubu.es/bitstream/10259/5321/1/Guembe-polymers_2020.pdf
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https://riubu.ubu.es/bitstream/10259/5321/5/Guembe-polymers_2020.pdf.txt
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