2024-03-28T10:25:38Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/42822022-12-20T11:21:21Zcom_10259_3593com_10259_5086com_10259_2604com_10259_4365com_10259_4883com_10259_3596col_10259_3594col_10259_4366col_10259_4884col_10259_3597
Gil García, Rubén
Ugalde, María
Busto Vázquez, Natalia
Lozano Ordóñez, Héctor J.
Leal Villalba, José María
Pérez, Begoña
Madariaga, Gotzon
Insausti, Maite
Lezama, Luis
Sanz Díez, Roberto
Gómez Sainz, Lidia M.
García Ruiz, Begoña
García Tojal, Javier
2016-11-24T08:30:17Z
2017-12-07T03:45:06Z
2016-12
1477-9226
http://hdl.handle.net/10259/4282
Thiosemicarbazones and their metal derivatives have long been screened as antitumor agents, and their interactions with DNA have been analysed. Herein, we describe the synthesis and characterization of compounds containing [CuL]+ entities (HL = pyridine-2-carbaldehyde thiosemicarbazone) and adenine, cytosine or 9-methylguanine, and some of their corresponding nucleotides. For the first time, crystal structures of adenine- and 9-methylguanine-containing thiosemicarbazone complexes are reported. To the best of our knowledge, the first study on the affinity thiosemicarbazone–RNA is also provided here. Experimental and computational studies have shown that [CuL(OH2)]+ entities at low concentration intercalate into dsRNA poly(rA)·poly(rU) through strong hydrogen bonds involving uracil residues and π–π stacking interactions. In fact, noncovalent interactions are present both in the solid state and in solution. This behaviour diverges from that observed with DNA duplexes and creates an optimistic outlook in achieving selective binding to RNA for subsequent possible medical applications.
eng
info:eu-repo/semantics/openAccess
Selectivity of a thiosemicarbazonatocopper(II) complex towards duplex RNA. Relevant noncovalent interactions both in solid state and solution
info:eu-repo/semantics/article