2024-03-28T09:37:02Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/58172022-05-20T13:23:36Zcom_10259_4141com_10259_5086com_10259_2604com_10259.4_2516col_10259_4142col_10259.4_2517
Albillos García, Silvia María
Montero, Olimpio
Calvo Meruelo, Sara
Solano, Berta
Trejo Gabriel y Galán, José Mª
Cubo Delgado, Esther
2021-06-28T09:38:03Z
2021-06-28T09:38:03Z
2021-05
http://hdl.handle.net/10259/5817
10.5334/tohm.600
2160-8288
Background: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson’s disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET).
Methods: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC).
Results: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60–0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53–0.84).
Conclusions: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET.
eng
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Atribución 4.0 Internacional
Parkinson’s disease
Essential tremor
alpha-synuclein
plasma biomarker
diagnosis
Can plasma α-Synuclein help us to differentiate parkinson’s disease from essential tremor?
info:eu-repo/semantics/article