2024-03-28T17:08:19Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/42972022-04-29T12:02:46Zcom_10259_4292com_10259_5086com_10259_2604com_10259.4_2516col_10259_4293col_10259.4_2517
Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells
Pino García, Raquel del
Gerardi, Gisela
Rivero Pérez, Maria Dolores
González San José, Mª Luisa
García Lomillo, Javier
Muñiz Rodríguez, Pilar
Colonic metabolites
Dietary antioxidants
Endothelial function
Hyperglycaemia
Redox signalling
Wine pomace
Food
Biochemistry
Molecular biology
Alimentos
Bioquímica
Biología molecular
Dietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial function
impairment observed in cardiovascular diseases. This study investigates the specific
protective effects of a vegetal seasoning obtained from seedless wine pomace against
hyperglycaemia-induced oxidative damage and dysfunction in human umbilical vein endothelial
cells EA.hy926. Non-cytotoxic doses of the bioactive compounds obtained following
in vitro digestion of the seasoning were used as treatments. Digested compounds, especially
colonic bacterial metabolites, restored a more balanced redox environment, prevented
lipid peroxidation and cell membrane damage, ameliorated protein oxidation, and improved
the balance between endothelial reactive oxygen species and nitric oxide production
in hyperglycaemic cells. Reduction of angiotensin I-converting enzyme activity and gene
modulation of superoxide dismutase, haem oxygenase-1, β-nicotinamide adenine dinucleotide
phosphate oxidase-4, and endothelial nitric oxide synthase are proposed as the
mechanisms underlying this protection.These results support the potential benefits of functional
wine pomace seasonings in vascular complications associated with oxidative stress.
Autonomous
Government of Castilla y León (Research project BU282U13).
The PhD grants of RDPG and JGL (FPU grants AP2010-1933 and
FPU12/05494) are funded by the Ministry of Education, Culture
and Sports, Spain.
2017-01-12T11:22:26Z
2017-04-01T02:45:06Z
2016-04
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
1756-4646
http://hdl.handle.net/10259/4297
eng
Journal of Functional Foods. 2016, V. 22, p. 1-612
http://dx.doi.org/10.1016/j.jff.2016.02.001
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
application/pdf
Elsevier