2024-03-28T23:38:43Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/44362022-04-29T12:02:48Zcom_10259_4313com_10259_5086com_10259_2604col_10259_4314
Inherent antibacterial activity and in vitro biocompatibility of hydrophilic polymer film containing chemically anchored sulfadiazine moieties
Morro, Ana
Abrusci, Concepción
Pablos, Jesús Luis
Marín, Irma
García García, Félix Clemente
García Pérez, José Miguel
PVP
Sulfadiazine
Antibacterial polymer
Biocompatible
Chemistry
Química
Microbial colonisation of synthetic materials is a great concern in many fields, e.g., in implant surgery and medical devices; therefore biocompatible hydrophilic organic materials with inherent antimicrobial properties are of current research interest. In this work, we describe the preparation of antibacterial and biocompatible polymeric film based on N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl acrylate (HEA), using ethyleneglycol dimethacrylate (EGDMA), and synthetic acrylic monomer containing sulfadiazine chemically anchored. The synthesised polyvinylpyrrolidone (PVP)-based films were characterized by different techniques (1H and 13C NMR, ATR-FTIR, SEM, and TGA). In this study, the biophysical responses of bacteria and L929 cells towards the prepared materials as model device surfaces were evaluated. The membrane that contains the anchored sulfadiazine moiety showed excellent antibacterial activity against Escherichia coli as well as good biocompatibility. Based on the experimental results, this material is a good candidate for medical applications as a biomaterial.
Spanish Ministerio de Economía y Competitividad-Feder
(MAT2014-54137-R and MAT2012-31709) and by the Consejería de Educación – Junta de Castilla y León – Feder (BU061U16)
2017-04-28T09:26:17Z
2019-06-01T02:45:06Z
2017-06
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://hdl.handle.net/10259/4436
eng
European Polymer Journal. 2017, V. 91, p. 274–282
https://doi.org/10.1016/j.eurpolymj.2017.04.012
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
application/pdf
Elsevier