2024-03-28T19:44:27Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/48762021-11-10T09:38:19Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
Hernando Santa Cruz, Elsa
Soto Cerrato, Vanessa
Cortés Arroyo, Susana .
Pérez Tomás, Ricardo
Quesada Pato, Roberto
Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have
been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in
model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the
alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of
these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50
values in the low micromolar range as well as modify the intracellular pH, inducing the basification of
acidic organelles.
2018-08-23T08:29:20Z
2018-08-23T08:29:20Z
2018-08-23T08:29:20Z
2014-03
info:eu-repo/semantics/article
1477-0520
http://hdl.handle.net/10259/4876
10.1039/c3ob42341g
eng
Organic & Biomolecular Chemistry. 2014, V. 12, n. 11, p. 1771-1778
https://doi.org/10.1039/c3ob42341g
info:eu-repo/grantAgreement/JCyL/BU340U13
info:eu-repo/grantAgreement/TV3Foundation/20132732
info:eu-repo/semantics/openAccess
Royal Society of Chemistry