2024-03-28T14:32:08Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259.4/25222021-11-10T09:38:25Zcom_10259.4_2520com_10259_5086com_10259_2604col_10259.4_2521
Carrillo Pérez, Celia
107
500
Cavia Camarero, María del Mar
115
500
Alonso de la Torre, Sara
20
500
2014-05-22T11:12:27Z
2014-05-22T11:12:27Z
2012
0212-1611
http://hdl.handle.net/10259.4/2522
10.3305/nh.2012.27.6.6010
Introduction: The beneficial effects of oleic acid in
cancer processes can no longer be doubted, but little is
known about the mechanisms of action behind this
phenomenon.
Aim: The aim of the present review is to clarify
whether oleic acid has an effect on important mechanisms
related to the carcinogenic processes. Aim: The aim of the present review is to clarify
whether oleic acid has an effect on important mechanisms related to the carcinogenic processes. Methods:We searched electronic databases and biblio -
graphies of selected articles were inspected for further reference. We focused our research on two cellular transformations characterizing cancer development: proliferation and cell death or apoptosis. Results: Numerous studies have reported an inhibition
in cell proliferation induced by oleic acid in different tumor cell lines. Herein, oleic acid could suppress the
over-expression of HER2 (erbB-2), a well-characterized
oncogene which plays a key role in the etiology, invasive
progression and metastasis in several human cancers. In
addition, oleic acid could play a role in intracellular
calcium signaling pathways linked to the proliferation
event. Regarding cell death, oleic acid has been shown to
induce apoptosis in carcinoma cells. The mechanisms
behind the apoptotic event induced by oleic acid could be
related to an increase in intracellular ROS production or
caspase 3 activity. Several unsaturated fatty acids have
been reported to induce apoptosis through a release of
calcium from intracellular stores. However, evidence
regarding such a role in oleic acid is lacking. Conclusions:Oleic acid plays a role in the activation of
different intracellular pathways involved in carcinoma cell development. Such a role could be the root of its antitumoral effects reported in clinical studies.
application/pdf
eng
Grupo Aula Médica
Nutrición Hospitalaria, 2012, v.27, n.6 (Noviembre-Diciembre), p. 1860-1865
http://dx.doi.org/10.3305%2Fnh.2012.27.6.6010
http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
Apoptosis
Oleic acid
Proliferation
Intracellular signaling
Ácido oleico
Proliferación celular
Señalización celular
Biología molecular
Molecular biology
Antitumor effect of oleic acid; mechanisms of action. A review
Efecto antitumoral del ácido oleico; mecanismos de acción: revisión científica
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
THUMBNAIL
6010.pdf.jpg
6010.pdf.jpg
IM Thumbnail
image/jpeg
3205
https://riubu.ubu.es/bitstream/10259.4/2522/4/6010.pdf.jpg
eba42a3dc85c16727609a33377f1b000
MD5
4
ORIGINAL
6010.pdf
6010.pdf
application/pdf
105017
https://riubu.ubu.es/bitstream/10259.4/2522/1/6010.pdf
c8fb335613af0c2d73013f81eb68e8ba
MD5
1
TEXT
6010.pdf.txt
6010.pdf.txt
Extracted text
text/plain
31248
https://riubu.ubu.es/bitstream/10259.4/2522/3/6010.pdf.txt
ea4f690e3717655459e6edecf1039427
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://riubu.ubu.es/bitstream/10259.4/2522/2/license.txt
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
10259.4/2522
oai:riubu.ubu.es:10259.4/2522
2021-11-10 10:38:25.353
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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