2024-03-28T12:36:36Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/47432022-04-29T12:02:46Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Knight, Nicola J. .
2366cbd0-fca0-47d5-a5e1-c8febb32c20e
500
Hernando Santa Cruz, Elsa
279
500
Haynes, Cally J. E. .
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500
Busschaert, Nathalie
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500
Clarke, Harriet J. .
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500
Takimoto, Koji
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500
García Valverde, María
222
500
Frey, Jeremy G. .
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500
Quesada Pato, Roberto
458
500
Gale, Philip A. .
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500
2018-03-07T10:33:46Z
2018-03-07T10:33:46Z
2016-02
2041-6520
http://hdl.handle.net/10259/4743
10.1039/c5sc03932k
The transmembrane anion transport activity of 43 synthetic molecules based on the structure of marine
alkaloid tambjamine were assessed in model phospholipid (POPC) liposomes. The anionophoric activity
of these molecules showed a parabolic dependence with lipophilicity, with an optimum range for
transport efficiency. Using a quantitative structure–transport activity (QSAR) approach it was possible to
rationalize these results and to quantify the contribution of lipophilicity to the transport activity of these
derivatives. While the optimal value of log P and the curvature of the parabolic dependence is a property
of the membrane (and so similar for the different series of substituents) we found that for relatively
simple substituents in certain locations on the tambjamine core, hydrophobic interactions clearly
dominate, but for others, more specific interactions are present that change the position of the
membrane hydrophobicity parabolic envelope.
RQ
acknowledges funding from Consejer´ıa de Educaci´on de la
Junta de Castilla y Le´on (Project BU340U13) and Fundaci´o la
Marat´o de TV3 (20132730). PAG thanks the EPSRC for funding
(EP/J009687/1 and EP/K039466/1). COST CM1005 Supramolecular Chemistry in
Water for a STSM (EH). JGF thanks the EPSRC (GR/R67729 & EP/
K003569) for funding
application/pdf
eng
Royal Society of Chemistry
Chemical Science. 2016, V. 7, n. 2, p. 1600-1608
https://doi.org/10.1039/c5sc03932k
info:eu-repo/grantAgreement/JCyL/BU340U13
info:eu-repo/grantAgreement/Fundació la Marató de TV3/20132730
info:eu-repo/grantAgreement/EPSRC/EP-J009687-1
info:eu-repo/grantAgreement/EPSRC/EP-K039466-1
info:eu-repo/grantAgreement/EPSRC/GR-R67729
info:eu-repo/grantAgreement/EPSRC/EP-
K003569
Attribution 3.0 Unported
http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
Chemistry, Organic
Química orgánica
QSAR analysis of substituent effects on tambjamine anion transporters
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
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Knight-CS_2016.pdf.jpg
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Knight-CS_2016.pdf
Knight-CS_2016.pdf
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license.txt
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TEXT
Knight-CS_2016.pdf.txt
Knight-CS_2016.pdf.txt
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https://riubu.ubu.es/bitstream/10259/4743/6/Knight-CS_2016.pdf.txt
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10259/4743
oai:riubu.ubu.es:10259/4743
2022-04-29 14:02:46.334
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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