2024-03-29T15:37:14Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/48762021-11-10T09:38:19Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Hernando Santa Cruz, Elsa
279
500
Soto Cerrato, Vanessa
346bb3c7-0c69-4d62-9045-26b0b8d37a51
500
Cortés Arroyo, Susana .
b0069a9f-e3d5-44f1-8bc7-b2dc8ac678b8
500
Pérez Tomás, Ricardo
3306d7a2-706a-47ab-8490-869a1b191c58
500
Quesada Pato, Roberto
458
500
2018-08-23T08:29:20Z
2018-08-23T08:29:20Z
2014-03
1477-0520
http://hdl.handle.net/10259/4876
10.1039/c3ob42341g
Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have
been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in
model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the
alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of
these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50
values in the low micromolar range as well as modify the intracellular pH, inducing the basification of
acidic organelles.
Consejería de Educación de la Junta de Castilla y León (Project
BU340U13) and Fundació la Maratón de TV3.
application/pdf
eng
Royal Society of Chemistry
Organic & Biomolecular Chemistry. 2014, V. 12, n. 11, p. 1771-1778
https://doi.org/10.1039/c3ob42341g
info:eu-repo/grantAgreement/JCyL/BU340U13
info:eu-repo/grantAgreement/TV3Foundation/20132732
Química orgánica
Chemistry, Organic
Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
info:eu-repo/semantics/openAccess
THUMBNAIL
Hernando-OBC_2014.pdf.jpg
Hernando-OBC_2014.pdf.jpg
IM Thumbnail
image/jpeg
3793
https://riubu.ubu.es/bitstream/10259/4876/5/Hernando-OBC_2014.pdf.jpg
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MD5
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LICENSE
license.txt
license.txt
text/plain; charset=utf-8
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https://riubu.ubu.es/bitstream/10259/4876/2/license.txt
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ORIGINAL
Hernando-OBC_2014.pdf
Hernando-OBC_2014.pdf
application/pdf
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https://riubu.ubu.es/bitstream/10259/4876/3/Hernando-OBC_2014.pdf
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TEXT
Hernando-OBC_2014.pdf.txt
Hernando-OBC_2014.pdf.txt
Extracted text
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39410
https://riubu.ubu.es/bitstream/10259/4876/4/Hernando-OBC_2014.pdf.txt
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10259/4876
oai:riubu.ubu.es:10259/4876
2021-11-10 10:38:19.607
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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