2024-03-28T20:17:02Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/53232022-04-07T10:19:07Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250
Rubio Martínez, Laura
492
500
Valverde Som, Lucía
583
500
Sarabia Peinador, Luis Antonio
534
500
Ortiz Fernández, Mª Cruz
406
500
2020-06-03T10:53:08Z
2020-06-03T10:53:08Z
2019-01
0039-9140
http://hdl.handle.net/10259/5323
10.1016/j.talanta.2019.120156
The simultaneous determination of 2,6-di-tert-butyl-4-methyl-phenol (BHT), benzophenone (BP), benzophenone-3 (BP3) and diisobutyl phthalate (DiBP) in seven sunscreen creams was carried out by gas chromatography/mass spectrometry (GC/MS) using DiBP-d4 as internal standard. The content of BP3, which is a UV filter, must not exceed 6% (w/w) in cosmetic products according to Regulation (EU) 2017/238 and the use of DiBP in cosmetic products shall be prohibited according to Regulation (EC) No 1223/2009.
The conclusions obtained with the univariate standard methodology in the identification of the analytes contained in the creams were wrong. However, a calibration based on PARAFAC or PARAFAC2 decompositions, where the samples of the prediction set were projected on the model obtained previously with the calibration set, enabled the unequivocal identification and quantification of the analytes even in the presence of interferents not considered in the calibration model. The PARAFAC2 decomposition was used to overcome the shifts in the retention time of BP and BP3. These three-way calibration techniques are needed to avoid false negative results. The method had not proportional or constant bias.
The presence of BHT was detected in the seven sunscreen creams analysed at an amount of 6.48 10−2%, 8.53 10−2%, 1.70 10−4%, 1.11 10−4%, 2.51 10−3%, 3.20 10−5% and 6.35 10−3%. The concentrations of DiBP found in four creams were 3.49 10−2%, 3.19 10−2%, 3.26 10−2% and 2.51 10−2%. On the other hand, BP was only detected in two of the cosmetic creams analysed at an amount of 7.84 10−3% and 1.04 10−2%. In addition, BP3 was detected in six of the creams at an amount of 4.73%, 3.49%, 4.94 10−3%, 1.98 10−3%, 6.62 10−1% and 1.73%. Therefore, none of the cosmetic creams contained BP3 in an amount higher than 6%.
Spanish MINECO (AEI/FEDER, UE) through project CTQ2017‐88894‐R and by Junta de Castilla y León through project BU012P17 (both co‐financed with European FEDER funds). L. Valverde-Som thanks JCyL for her postdoctoral contract through BU012P17 project.
application/pdf
eng
Elsevier
Talanta. 2019, V. 205, 120156
https://doi.org/10.1016/j.talanta.2019.120156
info:eu-repo/grantAgreement/MINECO/CTQ2017‐88894‐R
info:eu-repo/grantAgreement/JCyL/BU012P17
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
Benzophenone-3
PTV-GC/MS
PARAFAC
PARAFAC2
UV filter
Sunscreen cream
Química analítica
Chemistry, Analytic
Improvement in the identification and quantification of UV filters and additives in sunscreen cosmetic creams by gas chromatography/mass spectrometry through three-way calibration techniques
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
Talanta
205
120156
TEXT
Rubio-talanta_2019.pdf.txt
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oai:riubu.ubu.es:10259/5323
2022-04-07 12:19:07.363
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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