2024-03-29T10:44:10Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/58172022-05-20T13:23:36Zcom_10259_4141com_10259_5086com_10259_2604com_10259.4_2516col_10259_4142col_10259.4_2517
Albillos García, Silvia María
12
500
Montero, Olimpio
45bc4916-df2e-43c8-ae71-81bfffab3f0d
500
Calvo Meruelo, Sara
15e12f3e-6bd5-4d80-8016-33c3bca154de
500
Solano, Berta
a5e400d7-4d08-4e1f-90da-d5cdd1379201
500
Trejo Gabriel y Galán, José Mª
59c97f74-1692-42d2-9a8b-770c9f9b881f
500
Cubo Delgado, Esther
131
500
2021-06-28T09:38:03Z
2021-06-28T09:38:03Z
2021-05
http://hdl.handle.net/10259/5817
10.5334/tohm.600
2160-8288
Background: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson’s disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET).
Methods: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC).
Results: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60–0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53–0.84).
Conclusions: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET.
Junta de Castilla y León is acknowledged for funding through the Biomedicine open project call (Ref. BIO/BU06/14)
application/pdf
eng
Ubiquity Press
Tremor and Other Hyperkinetic Movements. 2021, V. 11, n. 1: 20, pp. 1–8.
https://doi.org/10.5334/tohm.600
info:eu-repo/grantAgreement/JCyL/BIO/BU06/14
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Parkinson’s disease
Essential tremor
alpha-synuclein
plasma biomarker
diagnosis
Bioquímica
Biología molecular
Biochemistry
Molecular biology
Can plasma α-Synuclein help us to differentiate parkinson’s disease from essential tremor?
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Tremor and Other Hyperkinetic Movements
11
1
THUMBNAIL
Albillos-tohm.pdf.jpg
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Albillos-tohm_2021.pdf
Albillos-tohm_2021.pdf
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10259/5817
oai:riubu.ubu.es:10259/5817
2022-05-20 15:23:36.198
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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