2024-03-28T09:40:44Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/64092022-11-11T11:02:04Zcom_10259_6168com_10259_5086com_10259_2604col_10259_6169
Rumbo Lorenzo, Carlos
505
600
Bianchin, Alvise
05820325-e214-40ec-a85f-0cd322ec5798
Locci, Antonio Mario
2c597749-a53c-4bc2-a72a-f6010f790859
600
Barros García, Rocío
787
500
Martel Martín, Sonia
790
500
Tamayo Ramos, Juan Antonio
547
600
2022-02-08T13:40:39Z
2022-02-08T13:40:39Z
2022-01
http://hdl.handle.net/10259/6409
10.1038/s41598-022-05406-5
2045-2322
The development of new candidate alloys with outstanding characteristics for their use in the aeronautical field is one of the main priorities for the sector. In this context, nanocrystaline (nc) alloys are considered relevant materials due to their special features, such as their exceptional physical and mechanical properties. However, another important point that needs to be considered with newly developed alloys is the potential toxicological impact that these materials may have in humans and other living organisms. The aim of this work was to perform a preliminary toxicological evaluation of three nc metal alloys (WCu, WAl and TiAl) in powder form produced by mechanical alloying, applying different in vitro assays, including a mix of W-Cu powders with standard grain size in the experiments to stablish comparisons. The effects of the direct exposure to powder suspensions and/or to their derived leachates were analysed in three model organisms representative of human and environmental exposures (the adenocarcinomic human alveolar basal epithelial cell line A549, the yeast Saccharomyces cerevisiae and the Gram negative bacterium Vibrio fischeri). Altogether, the results obtained provide new insights about the potential harmful effects of the selected nc alloys, showing that, from a toxicological perspective, nc TiAl is the safest candidate in the model organisms and conditions tested.
EU Horizon 2020 projects ICARUS (H2020-FETOPEN-2014-2015-RIA, grant agreement N° 713514) and ICARUS-INAS (FETOPEN-03-2018-2019-2020, Grant agreement N° 946174).
eng
Nature
Scientific Reports. 2022, V. 12, 1523
https://doi.org/10.1038/s41598-022-05406-5
info:eu-repo/grantAgreement/EC/H2020/713514/EU/ICARUS (Innovative Coarsening-resistant Alloys with enhanced Radiation tolerance and Ultra-fine -grained Structure for aerospace application)
info:eu-repo/grantAgreement/EC/H2020/946174/EU/ICARUS-INAS (Intregrated Nanostructures Assessment-Service for the biological impact analysis of nanostructures)
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Cell biology
Environmental impact
Microbiology
Biología molecular
Microbiología
Química física
Molecular biology
Microbiology
Chemistry, Physical and theoretical
Toxicological assessment of nanocrystalline metal alloys with potential applications in the aeronautical field
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Scientific Reports
12
1
THUMBNAIL
Rumbo-sr_2022.pdf.jpg
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https://riubu.ubu.es/bitstream/10259/6409/3/license.txt
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Rumbo-sr_2022.pdf
Rumbo-sr_2022.pdf
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10259/6409
oai:riubu.ubu.es:10259/6409
2022-11-11 12:02:04.327
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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