RT info:eu-repo/semantics/article
T1 Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients
A1 Izquierdo, María Jesús .
A1 Cavia Saiz, Mónica
A1 Muñiz Rodríguez, Pilar
A1 Francisco, Angel LM de .
A1 Arias, Manuel .
A1 Santos, Javier .
A1 Abaigar, Pedro
K1 Oxidative Stress
K1 Immunomodulation
K1 Receptors
K1 Calcitrio
K1 Paricalcitol
K1 19-nor-1alpha
K1 25-dihydroxyvitamin D2
K1 Bioquímica
K1 Biochemistry
K1 Biología molecular
K1 Molecular biology
AB Background: Treatment with selective vitamin D receptor activators such as paricalcitol have been shown to exertan anti-inflammatory effect in patients on hemodialysis, in addition to their action on mineral metabolism andindependently of parathyroid hormone (PTH) levels. The objective of this study was to evaluate the additionalantioxidant capacity of paricalcitol in a clinical setting.Methods: The study included 19 patients with renal disease on hemodialysis, of whom peripheral blood wasobtained for analysis at baseline and three months after starting intravenous paricalcitol treatment. The followingoxidizing and inflammatory markers were quantified: malondialdehyde (MDA), nitrites and carbonyl groups,indoleamine 2,3-dioxygenase (IDO), tumor necrosis factor alfa (TNF-α), interleukin-6 (IL-6), interleukin-18 (IL-18) andC-reactive protein (CRP). Of the antioxidants and anti-inflammatory markers, superoxide dismutase (SOD), catalase,reduced glutathione (GSH), thioredoxin, and interleukin-10 (IL-10) levels were obtained.Results: Baseline levels of oxidation markers MDA, nitric oxide and protein carbonyl groups significantly decreasedafter three months on paricalcitol treatment, while levels of GSH, thioredoxin, catalase and SOD activity significantlyincreased. After paricalcitol treatment, levels of the inflammatory markers CRP, TNF-α, IL-6 and IL-18 weresignificantly reduced in serum and the level of anti-inflammatory cytokine IL-10 was increased.Conclusions: In renal patients undergoing hemodialysis, paricalcitol treatment significantly reduces oxidative stressand inflammation, two well known factors leading to cardiovascular damage
PB BioMed Central
SN 1471-2369
YR 2012
FD 2012-11
LK http://hdl.handle.net/10259.4/2515
UL http://hdl.handle.net/10259.4/2515
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 26-abr-2024