RT info:eu-repo/semantics/article
T1 Antitumor effect of oleic acid; mechanisms of action. A review
T2 Efecto antitumoral del ácido oleico; mecanismos de acción: revisión científica
A1 Carrillo Pérez, Celia
A1 Cavia Camarero, María del Mar
A1 Alonso de la Torre, Sara
K1 Apoptosis
K1 Oleic acid
K1 Proliferation
K1 Intracellular signaling
K1 Ácido oleico
K1 Proliferación celular
K1 Señalización celular
K1 Biología molecular
K1 Molecular biology
AB Introduction: The beneficial effects of oleic acid incancer processes can no longer be doubted, but little isknown about the mechanisms of action behind thisphenomenon.Aim: The aim of the present review is to clarifywhether oleic acid has an effect on important mechanismsrelated to the carcinogenic processes. Aim: The aim of the present review is to clarifywhether oleic acid has an effect on important mechanisms related to the carcinogenic processes. Methods:We searched electronic databases and biblio -graphies of selected articles were inspected for further reference. We focused our research on two cellular transformations characterizing cancer development: proliferation and cell death or apoptosis. Results: Numerous studies have reported an inhibitionin cell proliferation induced by oleic acid in different tumor cell lines. Herein, oleic acid could suppress theover-expression of HER2 (erbB-2), a well-characterizedoncogene which plays a key role in the etiology, invasiveprogression and metastasis in several human cancers. Inaddition, oleic acid could play a role in intracellularcalcium signaling pathways linked to the proliferationevent. Regarding cell death, oleic acid has been shown toinduce apoptosis in carcinoma cells. The mechanismsbehind the apoptotic event induced by oleic acid could berelated to an increase in intracellular ROS production orcaspase 3 activity. Several unsaturated fatty acids havebeen reported to induce apoptosis through a release ofcalcium from intracellular stores. However, evidenceregarding such a role in oleic acid is lacking. Conclusions:Oleic acid plays a role in the activation ofdifferent intracellular pathways involved in carcinoma cell development. Such a role could be the root of its antitumoral effects reported in clinical studies.
PB Grupo Aula Médica
SN 0212-1611
YR 2012
FD 2012
LK http://hdl.handle.net/10259.4/2522
UL http://hdl.handle.net/10259.4/2522
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 25-abr-2024