RT info:eu-repo/semantics/article T1 Autoantibodies against type I IFNs in patients with life-threatening COVID-19 A1 Bastard, Paul A1 Rosen, Lindsey B. A1 Zhang, Qian A1 Michailidis, Eleftherios A1 Hoffmann, Hans-Heinrich A1 Zhang, Yu A1 Dorgham, Karim A1 Philippot, Quentin A1 Rosain, Jérémie A1 Béziat, Vivien A1 Manry, Jérémy A1 Shaw, Elana A1 Haljasmägi, Liis A1 Peterson, Pärt A1 Lorenzo, Lazaro A1 Bizien, Lucy A1 Trouillet-Assant, Sophie A1 Dobbs, Kerry A1 de Jesus, Adriana Almeida A1 Belot, Alexandre A1 Kallaste, Anne A1 Catherinot, Emilie A1 Tandjaoui-Lambiotte, Yacine A1 Le Pen, Jeremie A1 Kerner, Gaspard A1 Bigio, Benedetta A1 Seeleuthner, Yoann A1 Yang, Rui A1 Bolze, Alexandre A1 Spaan, András N. A1 Delmonte, Ottavia M. A1 Abers, Michael S. A1 Aiuti, Alessandro A1 Casari, Giorgio A1 Lampasona, Vito A1 Piemonti, Lorenzo A1 Ciceri, Fabio A1 Bilguvar, Kaya A1 Lifton, Richard P. A1 Vasse, Marc A1 Smadja, David M. A1 Migaud, Mélanie A1 Hadjadj, Jérome A1 Terrier, Benjamin A1 Duffy, Darragh A1 Quintana-Murci, Lluis A1 van de Beek, Diederik A1 Roussel, Lucie A1 Vinh, Donald C. A1 Tangye, Stuart G. A1 Haerynck, Filomeen A1 Dalmau, David A1 Martinez-Picado, Javier A1 Brodin, Petter A1 Nussenzweig, Michel C. A1 Boisson-Dupuis, Stéphanie A1 Rodríguez-Gallego, Carlos A1 Vogt, Guillaume A1 Mogensen, Trine H. A1 Oler, Andrew J. A1 Gu, Jingwen A1 Burbelo, Peter D. A1 Cohen, Jeffrey I. A1 Biondi, Andrea A1 Bettini, Laura Rachele A1 D'Angio, Mariella A1 Bonfanti, Paolo A1 Rossignol, Patrick A1 Mayaux, Julien A1 Rieux-Laucat, Frédéric A1 Husebye, Eystein S. A1 Fusco, Francesca A1 Ursini, Matilde Valeria A1 Imberti, Luisa A1 Sottini, Alessandra A1 Paghera, Simone A1 Quiros-Roldan, Eugenia A1 Rossi, Camillo A1 Castagnoli, Riccardo A1 Montagna, Daniela A1 Licari, Amelia A1 Marseglia, Gian Luigi A1 Duval, Xavier A1 Ghosn, Jade A1 Tsang, John S. A1 Goldbach-Mansky, Raphaela A1 Kisand, Kai A1 Lionakis, Michail S. A1 Puel, Anne A1 Zhang, Shen-Ying A1 Holland, Steven M. A1 Gorochov, Guy A1 Jouanguy, Emmanuelle A1 Rice, Charles M. A1 Cobat, Aurélie A1 Notarangelo, Luigi D. A1 Abel, Laurent A1 Su, Helen C. A1 Casanova, Jean-Laurent A1 Arias, Andrés Augusto A1 Boisson, Bertrand A1 Boucherit, Soraya A1 Bustamante, Jacinta A1 Chbihi, Marwa A1 Chen, Jie A1 Chrabieh, Maya A1 Kochetkov, Tatiana A1 Le Voyer, Tom A1 Liu, Dana A1 Nemirovskaya, Yelena A1 Ogishi, Masato A1 Papandrea, Dominick A1 Patissier, Cécile A1 Rapaport, Franck A1 Roynard, Manon A1 Vladikine, Natasha A1 Woollett, Mark A1 Zhang, Peng A1 Kashyap, Anuj A1 Ding, Li A1 Bosticardo, Marita A1 Wang, Qinlu A1 Ochoa, Sebastian A1 Liu, Hui A1 Chauvin, Samuel D. A1 Stack, Michael A1 Koroleva, Galina A1 Bansal, Neha A1 Dalgard, Clifton L. A1 Snow, Andrew L. A1 Abad, Jorge A1 Aguilera-Albesa, Sergio A1 Akcan, Ozge Metin A1 Darazam, Ilad Alavi A1 Aldave, Juan C. 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Joost A1 Wouters, Dorien A1 Zwinderman, A. H. (Koos) A1 Al Muhsen, Saleh A1 Al-Mulla, Fahd A1 Anderson, Mark S. A1 Bogunovic, Dusan A1 Bondarenko, Anastasiia A1 Bryceson, Yenan A1 Bustamante, Carlos D. A1 Butte, Manish A1 Chakravorty, Samya A1 Christodoulou, John A1 Cirulli, Elizabeth A1 Condino-Neto, Antonio A1 Cooper, Megan A. A1 DeRisi, Joseph L. A1 Desai, Murkesh A1 Drolet, Beth A. A1 Espinosa, Sara A1 Franco, Jose Luis A1 Gregersen, Peter K. A1 Hagin, David A1 Heath, Jim A1 Henrickson, Sarah E. A1 Hsieh, Elena A1 Imai, Kohsuke A1 Itan, Yuval A1 Karamitros, Timokratis A1 Ku, Cheng-Lung A1 Ling, Yun A1 Lucas, Carrie L. A1 Maniatis, Tom A1 Mansouri, Davoud A1 Marodi, Laszlo A1 Milner, Joshua D. A1 Mironska, Kristina A1 Mogensen, Trine A1 Morio, Tomohiro A1 Novelli, Giuseppe A1 Novelli, Antonio A1 O'Farrelly, Cliona A1 Okada, Satoshi A1 Ozcelik, Tayfun A1 de Diego, Rebeca Perez A1 Planas, Anna M. A1 Prando, Carolina A1 Pujol, Aurora A1 Renia, Laurent A1 Renieri, Alessandra A1 Sancho-Shimizu, Vanessa A1 Sankaran, Vijay A1 Barrett, Kelly Schiabor A1 Shahrooei, Mohammed A1 Snow, Andrew A1 Tangye, Stuart A1 Turvey, Stuart A1 Uddin, Furkan A1 Uddin, Mohammed J. A1 Vazquez, Sara E. A1 von Bernuth, Horst A1 Washington, Nicole A1 Zawadzki, Pawel K1 Medicina K1 Medicine AB Interindividual clinical vari-ability is vast in humans infected withsevere acute respiratory syndrome corona-virus 2 (SARS-CoV-2), ranging from silent in-fection to rapid death. Three risk factors forlife-threatening coronavirus disease 2019(COVID-19) pneumonia have been identified—being male, being elderly, or having othermedical conditions—but these risk factorscannot explain why critical disease remainsrelatively rare in any given epidemiologicalgroup. Given the rising toll of the COVID-19pandemic in terms of morbidity and mortality,understanding the causes and mechanisms oflife-threatening COVID-19 is crucial. PB American Association for the Advancement of Science SN 0036-8075 YR 2020 FD 2020-09 LK http://hdl.handle.net/10259/10039 UL http://hdl.handle.net/10259/10039 LA spa NO The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, The Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, the Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the Investments for the Future program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANRS-COV05), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, the Institut Institut National de la Santé et de la Recherche Médicale (INSERM), and the University of Paris. Samples from San Raffaele Hospital were obtained through the Covid-BioB project and by healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical laboratory and clinical research unit, funded by the Program Project COVID-19 OSR-UniSR and Fondazione Telethon. The French COVID Cohort Study Group was sponsored by INSERM and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). The Milieu Intérieur Consortium was supported by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence Milieu Intérieur grant (ANR-10-LABX-69-01) (primary investigators: L.Q.-M. and D.Du.). The Simoa experiment was supported by the PHRC-20-0375 COVID-19 grant “DIGITAL COVID” (primary investigator: G.G.). S.G.T. is supported by a Leadership 3 Investigator Grant awarded by the National Health and Medical Research Council of Australia and a COVID19 Rapid Response Grant awarded by UNSW Sydney. C.R.-G. and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry of Science and Innovation RTC-2017-6471-1; AEI/FEDER, UE) and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). S.T.-A. and A.B. were supported by ANR-20-COVI-0064 (primary investigator: A.Be.). This work is supported by the French Ministry of Health “Programme Hospitalier de Recherche Clinique Inter regional 2013,” by the Contrat de Plan Etat-Lorraine and FEDER Lorraine, and by a public grant overseen by the French National Research Agency (ANR) as part of the second Investissements d’Avenir program FIGHT-HF (reference no. ANR-15-RHU-0004) and by the French PIA project “Lorraine Université d’Excellence” (reference no. ANR-15-IDEX-04-LUE) (45); and biobanking is performed by the Biological Resource Center Lorrain BB-0033-00035. This study was supported by the Fonds IMMUNOV, for Innovation in Immunopathology; by a grant from the Agence National de la Recherche (ANR-flash Covid19 “AIROCovid” to F.R.-L.); and by the FAST Foundation (French Friends of Sheba Tel Hashomer Hospital). Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1; a George Mason University Fast Grant; and the G. Harold and Leila Y. Mathers Charitable Foundation. The Amsterdam UMC Covid-19 Biobank was supported by grants from the Amsterdam Corona Research Fund, the Dr. C.J. Vaillant Fund, and the Netherlands Organization for Health Research and Development [ZonMw; NWO-Vici-Grant (grant no. 918·19·627 to D.v.d.B.)]. This work was also supported by the Division of Intramural Research of the National Institute of Dental Craniofacial Research and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Regione Lombardia, Italy (project “Risposta immune in pazienti con COVID-19 e comorbidita”). The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. J.H. holds an Institut Imagine M.D.-Ph.D. fellowship from the Fondation Bettencourt Schueller. J.R. is supported by the INSERM Ph.D. program (“poste d’accueil Inserm”). P.Ba. was supported by the French Foundation for Medical Research (FRM, EA20170638020) and the M.D.-Ph.D. program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). We thank the Association “Turner et vous” for their help and support. Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. D.C.V. is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. K.K. was supported by the Estonian Research Council grant PUT1367. We thank the GEN-COVID Multicenter Study (https://sites.google.com/dbm.unisi.it/gen-covid). We thank the NIAID Office of Cyber Infrastructure and Computational Biology, Bioinformatics and Computational Biosciences Branch (contract no. HHSN316201300006W/HHSN27200002 to MSC, Inc.), the Operations Engineering Branch for developing the HGRepo system to enable streamlined access to the data, and the NCI Advanced Biomedical Computational Science (ABCS) for data transformation support. Biomedical Advanced Research and Development Authority was supported under contract no. HHSO10201600031C (to J.H.). Financial support was provided by the National Institute of Allergy and Infectious Diseases (NIAID) K08AI135091; the Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; and the American Academy of Allergy, Asthma, and Immunology. DS Repositorio Institucional de la Universidad de Burgos RD 03-mar-2025