RT info:eu-repo/semantics/article
T1 Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer’s disease
A1 Wiloch, Magdalena Z.
A1 Pérez Estébanez, Martín
A1 Baran, Natalia
A1 Heras Vidaurre, Aránzazu
A1 Jönsson-Niedziółka, Martin
A1 Colina Santamaría, Álvaro
K1 Voltammetry
K1 TDMQ20
K1 Spectroelectrochemistry
K1 Alzheimer’s disease
K1 Química analítica
K1 Chemistry, Analytic
K1 Electroquímica
K1 Electrochemistry
AB Alzheimer’s Disease (AD), reported for the first time in 1906, is a common disease that remains incurable to this day. In the past, a family of treatments using Cu(II) chelators failed during clinical trials, evidencing the importance of pre-clinical studies. In this work, we performed electrochemical characterisation of TDMQ20, a new potential drug against AD, using electrochemistry and spectroelectrochemistry. On the basis of voltammetry, we determined that TDMQ20 undergoes a two-step irreversible oxidation process and a one-step irreversible reduction process. Both oxidation and reduction reactions are pH-sensitive. Bidimensional UV–Vis spectroelectrochemistry (UV–Vis-SEC) allowed us to confirm that oxidation of TDMQ20 can occur both on the aliphatic chain and on the aromatic ring. The results expand the knowledge of the TDMQ20 redox activity in the human body which is important from the point of view of the toxicity of the proposed therapy.
PB Elsevier
SN 1567-5394
YR 2025
FD 2025
LK http://hdl.handle.net/10259/10050
UL http://hdl.handle.net/10259/10050
LA eng
NO This work has been financially supported by the National Science Centre Poland within the Sonatina project 2021/40/C/ST4/00090.
DS Repositorio Institucional de la Universidad de Burgos
RD 12-mar-2025