RT info:eu-repo/semantics/article
T1 Gold-Catalyzed “Back-to-Front” Synthesis of 4-Silyloxyindoles
A1 Muñoz Torres, Miguel Ángel
A1 Suárez Pantiga, Samuel
A1 Sanz Díez, Roberto
K1 Química
K1 Chemistry
K1 Química orgánica
K1 Chemistry, Organic
AB A series of pyrrol-yn-glycol derivatives were easily prepared from simple pyrroles through a three-step sequence involving hydroxyalkylation-alkynylation-O-silylation. Their reaction with IPrAuNTf2 triggers a C2-pyrrole attack onto the activated alkyne and subsequent highly selective 1,2-migration of the oxyalkyl group in the intermediate spirocycle. This approach enables the efficient synthesis of a wide selection of regioselectively functionalized 4-hydroxyindoles, which represent important yet challenging indole scaffolds, in high yields.
PB American Chemical Society
SN 1523-7060
YR 2024
FD 2024-06
LK http://hdl.handle.net/10259/10500
UL http://hdl.handle.net/10259/10500
LA eng
NO We gratefully acknowledge Ministerio de Ciencia e Innovación(PID2020-115789GB-C21/AEI/10.13039/501100011033), and Junta de Castilla y León and FEDER (BU028P23) forfinancial support. M.A. M.-T. thanks Junta de Castilla y Leónand Fondo Social Europeo for a predoctoral contract. S.S.-P.thanks Ministerio de Ciencia e Innovación and “NextGener-ationEU”/PRTR EU for a Ramón y Cajal contract (RYC2021-031533-I).
DS Repositorio Institucional de la Universidad de Burgos
RD 30-may-2025