RT info:eu-repo/semantics/article
T1 Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols
A1 Gómez Gil, Sara
A1 Cases, Nuria
A1 Hernández Ruiz, Raquel
A1 Rubio Presa, Rubén
A1 Suárez Pantiga, Samuel
A1 Pedrosa Sáez, María de los Remedios
A1 Sanz Díez, Roberto
K1 Química
K1 Chemistry
AB We report the efficient, sustainable one-pot synthesis of a wide variety of N-polyheterocycles, such as imidazo-quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction-imine formation-intramolecular cyclization-oxidation sequence. It is worth highlighting that the recycling and incorporation of the waste carbonyl byproduct, generated in the reduction step, into the final compound is realized. In addition, the overall efficiency and atom economy of the process are further improved owing to the participation of one reaction intermediate as reductant that allows lowering the amount of external reducing agent employed.
PB Wiley
SN 1434-193X
YR 2024
FD 2024-03
LK http://hdl.handle.net/10259/10502
UL http://hdl.handle.net/10259/10502
LA eng
NO We gratefully acknowledge Ministerio de Ciencia e Innovación (PID2020-115789GB−C21/AEI/10.13039/501100011033), and Junta de Castilla y León and FEDER (BU028P23) for financial support. S.G.-G. thanks Ministerio de Educación for a FPU predoctoral contract. S.S.-P. thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MCIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR.
DS Repositorio Institucional de la Universidad de Burgos
RD 30-may-2025