RT info:eu-repo/semantics/article
T1 Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions
A1 Gómez Ayuso, Javier
A1 Carreira Barral, Israel
A1 Quesada Pato, Roberto
A1 García Valverde, María
K1 Multicomponent reactions
K1 Radical reactions
K1 Copper catalys
K1 Succinimide
K1 Spirosuccinimide
K1 Spiro-2H-pyrrole
K1 Química orgánica
K1 Chemistry, Organic
AB Herein we present a novel one-pot methodology for the synthesis of enantioenriched 2H-pyrrolespirosuccinimides by copper-catalyzed reactions on Ugi adducts derived from enantiopure α-alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen radical-shuttle (HRS) process explains the chemical and stereochemical results. This work demonstrates the efficient stereoselective synthesis of structurally unique, highly functionalized nitrogen heterocyclic systems using simple protocols and affordable starting materials.
PB Wiley
SN 1615-4150
YR 2025
FD 2025-05
LK https://hdl.handle.net/10259/10644
UL https://hdl.handle.net/10259/10644
LA eng
NO We thank funding from MICIU/AEI/10.13039/501100011033 and ERDF, UE (grants PID2020-117610RB−I00 and PID2023-151848OB−I00) and Consejería de Educación de la Junta de Castilla y León and ERDF, UE (Project BU067P20). J. G.-A. thanks Consejería de Educación de la Junta de Castilla y León and ERDF, UE for his predoctoral and post-doctoral contracts.
DS Repositorio Institucional de la Universidad de Burgos
RD 21-abr-2026