RT info:eu-repo/semantics/article
T1 Genomic Characterization of Campylobacter jejuni Associated with Perimyocarditis: A Family Case Report
A1 Ortega Sanz, Irene
A1 García, Marcial .
A1 Bocigas, Carolina
A1 Megías, Gregoria
A1 Melero Gil, Beatriz
A1 Rovira Carballido, Jordi
K1 Campylobacteriosis
K1 Perimyocarditis
K1 Clinical case
K1 Phase variation
K1 Virulence genes
K1 Antimicrobial resistance genes
K1 Microbiología
K1 Microbiology
K1 Enfermedades de origen alimentario
K1 Foodborne diseases
AB Campylobacter spp. is the leading cause of foodborne gastrointestinal infections in humans worldwide. This study reports the first case of four family members who had contact with the same source of Campylobacter jejuni contamination with different results. Only the little siblings were infected by the same C. jejuni strain, but with different symptoms. Whereas the daughter was slightly affected with mild enteritis, the son suffered a longer campylobacteriosis followed with a perimyocarditis. This is the first case of the youngest patient affected by C. jejuni-related perimyocarditis published to date. The genomes of both strains were characterized by whole-genome sequencing and compared with the C. jejuni NCTC 11168 genome to gain insights into the molecular features that may be associated with perimyocarditis. Various comparison tools were used for the comparative genomics analysis, including the identification of virulence and antimicrobial resistance genes, phase variable (PV) genes, and single nucleotide polymorphisms (SNPs) identification. Comparisons of the strains identified 16 SNPs between them, which constituted small but significant changes mainly affecting the ON/OFF state of PV genes after passing through both hosts. These results suggest that PV occurs during human colonization, which modulates bacteria virulence through human host adaptation, which ultimately is related to complications after a campylobacteriosis episode depending on the host status. The findings highlight the importance of the relation between host and pathogen in severe complications of Campylobacter infections.
PB SAGE Publications
SN 1535-3141
YR 2023
FD 2023-08
LK https://hdl.handle.net/10259/11268
UL https://hdl.handle.net/10259/11268
LA eng
NO The project leading to these results has received funding from “La Caixa” Foundation and Caja Burgos Foundation, under agreement LCF/PR/PR18/51130007. I.O.-S. received a predoctoral grant from the Junta of Castile and León, cofinanced by the Ministry of Education of the Government of Castile and León and the European Social Fund.
DS Repositorio Institucional de la Universidad de Burgos
RD 21-abr-2026