RT info:eu-repo/semantics/article
T1 Photostable Iridium(III) Cyclometallated Complex is an Efficient Photosensitizer for Killing Multiple Cancer Cell Lines and 3D Models under Low Doses of Visible Light
A1 Jones, Callum G.
A1 Martínez Alonso, Marta
A1 Gagg, Hannah
A1 Kirby, Liam
A1 Weinstein, Julia A.
A1 Bryant, Helen E.
K1 Fotoquimioterapia
K1 Photochemotherapy
K1 Cáncer-Quimioterapia
K1 Cancer-Chemotherapy
AB Photodynamic therapy delivers more targeted cell killing than classical chemotherapy. It uses light-absorbing compounds, photosensitizers (PSs), to generate lethal reactive oxygen species (ROS) at sites of localized irradiation. Transition metal complexes are attractive PSs due to their photostability, visible-light absorption, and high ROS yields. Here, we introduce a low-molecular weight, photostable iridium complex, [Ir(thpy)2(benz)]Cl, 1, that localizes to the Golgi apparatus, mitochondria, and endoplasmic reticulum, absorbs visible light, phosphoresces strongly, generates 1O2 with 43% yield, and undergoes cellular elimination after 24 h. 1 shows low dark toxicity and under remarkably low doses (3 min, 20–30 mJ s–1 cm–2) of 405 or 455 nm light, it causes killing of bladder (EJ), malignant melanoma (A375), and oropharyngeal (OPSCC72) cancer cells, with high phototoxic indices > 100–378. 1 is also an efficient PS in 3D melanoma spheroids, with repeated short-time irradiation causing cumulative killing.
PB American Chemical Society
SN 0022-2623
YR 2024
FD 2024-09
LK https://hdl.handle.net/10259/11324
UL https://hdl.handle.net/10259/11324
LA eng
NO Funded by The University of Sheffield, Rosetrees Trust M698, Wellcome Trust WT093134AIA, the EPSRC, and the Fundacioń Alfonso Martí n Escudero (Spain).
DS Repositorio Institucional de la Universidad de Burgos
RD 27-abr-2026