RT info:eu-repo/semantics/article
T1 Advanced strategies in the design of Ir(III) biscyclometalated complexes for PDT
A1 Sanz Villafruela, Juan
A1 Carbayo Martín, Mª Aránzazu
A1 Martínez Alonso, Marta
A1 Espino Ordóñez, Gustavo
K1 Cyclometalated Ir(III) complexes
K1 Medicinal chemistry
K1 Anticancer
K1 Photodynamic therapy
K1 PDT
K1 Bioinorganic chemistry
K1 Farmacología
K1 Pharmacology
K1 Oncología
K1 Oncology
AB Photodynamic therapy (PDT) is a slightly invasive modality of chemotherapy that is arising as a new alternative for the clinical treatment of cancer and other illnesses. This therapy is based on the use of a photosensitiser (PS) which can be activated locally and specifically upon light irradiation to generate reactive oxygen species (ROS) which damage key biomolecules, leading to cancer cell death and tumour regression. This control in the cytotoxicity thanks to the activation of the PS, benefits from a reduction of the undesirable side-effects of the common chemotherapeutics. Among the wide variety of photosensitisers, Ir(III) complexes stand out due to their exceptional photophysical properties and high photostability. In the last years, there have been substantial advances in the development of new Ir(III) scaffolds that have allowed to overcome some of the limitations of PDT and might contribute to a wider clinical development. In this review, we feature the latest and cutting-edge strategies that have been recently employed in the design of new Ir(III) complexes to increase both their light harvesting ability in the therapeutic window and their photodynamic efficiency, to achieve a better biocompatibility, to increase the selectivity towards cancer cells or specific organelles and the possibility of using a combination of PDT with other advanced therapies to enhance the therapeutic effect.
PB Elsevier
SN 0010-8545
YR 2025
FD 2025-07
LK https://hdl.handle.net/10259/11335
UL https://hdl.handle.net/10259/11335
LA eng
NO The authors gratefully acknowledge financial support from the MCIN/AEI of Spain (PID2021-127187OB-C21). We acknowledge Universidad de Burgos for postdoctoral and predoctoral grants Burgos (M.M.A, 2021/00002/001/001, María Zambrano grant, funded by European Union - NextGenerationEU and J.S.V., 2019/00002/008/001).
DS Repositorio Institucional de la Universidad de Burgos
RD 29-abr-2026