RT info:eu-repo/semantics/article
T1 Inert cationic iridium(iii) complexes with phenanthroline-based ligands: application in antimicrobial inactivation of multidrug-resistant bacterial strains
A1 Busto Vázquez, Natalia
A1 Vigueras, Gloria
A1 Cutillas, Natalia
A1 García Ruiz, Begoña
A1 Ruiz, José
K1 Compuestos organometálicos
K1 Organometallic compounds
K1 Bacterias patógenas
K1 Pathogenic bacteria
AB The antimicrobial activity of a new series of heteroleptic iridium(III) complexes of the type [Ir(C^N)2(N^N)][PF6] (C^N = deprotonated 2-phenylbenzimidazole-κN, κC; N^N = phen (Ir1), dpq (Ir2), dppz (Ir3), dppn (Ir4), and dppz-idzo (Ir5)) was studied towards two Gram positive (vancomycin-resistant Enterococcus faecium and a methicillin-resistant Staphylococcus aureus) and two Gram negative (Acinetobacter baumanii and Pseudomonas aeruginosa) multidrug-resistant bacterial strains of clinical interest. Although the complexes were inactive towards Gram negative bacteria, their effectiveness against Gram positive strains was remarkable, especially for Ir1 and Ir2, the most bactericidal complexes that were even more active (10 times) than the fluoroquinolone antibiotic norfloxacin and displayed no toxicity in human kidney cells (HEK293). Mechanistic studies revealed that the cell wall and membrane of MRSA S. aureus remained intact on treatment with these compounds and that DNA was not their main target. It is important to note that the complexes were able to induce ROS generation, this being the feature key to their antimicrobial activity.
PB Royal Society of Chemistry
SN 1477-9226
YR 2022
FD 2022-07
LK https://hdl.handle.net/10259/11392
UL https://hdl.handle.net/10259/11392
LA eng
NO This work was supported by the Spanish Ministerio de Ciencia e Innovación (MCI/AEI) and FEDER funds (Projects RTI2018-096891-B-I00, RTI2018-102040-B-100 and MultiMetDrugs network RED2018-102471-T), Fundación Séneca-Región de Murcia (project 20857/PI/18), Consejería de Educación-Junta de Castilla y León-FEDER (BU042U16-BU305P18) and “la Caixa” Banking Foundation (LCF/PR/PR12/11070003). G.V. thanks the University of Murcia for a grant (R-1034/2016).
DS Repositorio Institucional de la Universidad de Burgos
RD 20-abr-2026