RT info:eu-repo/semantics/article
T1 Influence of N-Acetylcysteine Supplementation on Physical Performance and Laboratory Biomarkers in Adult Males: A Systematic Review of Controlled Trials
A1 Fernández-Lázaro, Diego
A1 Domínguez-Ortega, Carlos
A1 Busto Vázquez, Natalia
A1 Santamaría Peláez, Mirian
A1 Roche, Enrique
A1 Gutiérez-Abejón, Eduardo
A1 Mielgo Ayuso, Juan
K1 N-acetylcysteine
K1 Sport supplementation
K1 Physical performance
K1 Safety
K1 Oxidative stress
K1 Antioxidant
K1 Glutathione homeostasis
K1 Laboratory biomarkers
K1 Deportistas-Alimentación
K1 Athletes-Nutrition
AB N-acetylcysteine (NAC) is used as a sports supplement for its ability to modulate exerciseinducedoxidative damage through its antioxidant actions and maintenance of glutathione homeostasis,positioning NAC as a strategy to improve physical performance. We aimed to evaluate the current evidence on the benefits of NAC supplementation on physical performance and laboratory biomarkers in adult men. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed studies indexed in the Web of Science, Scopus, and PubMed to assess the effects of NAC on physical performance, laboratory biomarkers, and adverse effects in adult men. Original articles published up to 30 April 2023 with a controlled trial design comparing NAC supplementation with a control group were included. The modified McMaster Critical Review Form for Quantitative Studies was used as an assessment tool and the Cochrane Risk of Bias was applied. Of the 777 records identified in the search, 16 studies met the inclusion and exclusion criteria. Overall, most of the trials reported beneficial effects of NAC supplementation and no serious adverse events were reported. Participants supplemented with NAC showed significant improvements in exercise performance, antioxidant capacity, and glutathione homeostasis. However, there was no clear evidence of beneficial effects of NAC supplementation on haematological markers, inflammatory response, and muscle behaviour. NAC supplementation appears to be safe and may regulate glutathione homeostasis, have antioxidant effects, and improve exercise performance. However, further studies are needed to clarify the relevance of its use.
PB MDPI
SN 2072-6643
YR 2023
FD 2023-05
LK https://hdl.handle.net/10259/11891
UL https://hdl.handle.net/10259/11891
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 02-jul-2026