RT info:eu-repo/semantics/article T1 Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial A1 Martínez Ferrán, María A1 Cuadrado-Peñafiel, Víctor A1 Sánchez-Andreo, Juan Manuel A1 Villar-Lucas, Marta A1 Castellanos-Montealegre, Mónica A1 Rubio-Martín, Agustín A1 Romero-Morales, Carlos A1 Casla-Barrio, Soraya A1 Pareja-Galeano, Helios K1 Antioxidants K1 Ascorbic acid K1 Tocopherols K1 Athletic performance K1 Muscle damage K1 Suplementos nutricionales K1 Dietary supplements K1 Atletas-Nutrición K1 Athletes-Nutrition AB Considering the existing controversy over the possible role of acute antioxidant vitamins in reducing exercise-induced muscle damage (EIMD), this doubled-blind, randomized and controlled trial aimed to determine whether supplementation with vitamins C and E could mitigate the EIMD in endurance-trained runners (n = 18). The exercise protocol involved a warm-up followed by 6 to 8 bouts of 1 km running at 75% maximum heart rate (HRmax). Two hours before the exercise protocol, participants took the supplementation with vitamins or placebo, and immediately afterwards, blood lactate, rate of perceived exertion and performance were assessed. At 24 h post-exercise, CK, delayed onset muscle soreness and performance were determined (countermovement jump, squat jump and stiffness test). The elastic index and vertical stiffness were calculated using a stiffness test. Immediately after the exercise protocol, all participants showed improved maximum countermovement jump, which only persisted after 24 h in the vitamin group (p < 0.05). In both groups, squat jump height was significantly greater (p < 0.05) immediately after exercise and returned to baseline values after 24 h. The elastic index increased in the vitamin group (p < 0.05), but not in the placebo group. In both groups, lactate levels increased from pre- to immediately post-exercise (p < 0.05), and CK increased from pre- to 24 h post-exercise (p < 0.05). No significant differences between groups were observed in any of the variables (p > 0.05). Vitamin C and E supplementation does not seem to help with EIMD in endurance-trained individuals. PB MDPI YR 2022 FD 2022-11 LK https://hdl.handle.net/10259/11903 UL https://hdl.handle.net/10259/11903 LA eng DS Repositorio Institucional de la Universidad de Burgos RD 11-jul-2026