RT info:eu-repo/semantics/article
T1 The association between lifestyle factors and mortality in Huntington's disease
A1 Cubo Delgado, Esther
A1 Rivadeneyra Posadas, Jéssica Jannett
A1 Simón Vicente, Lucía
A1 Aguado, Laura
A1 Calvo Simal, Sara
A1 Saiz Rodríguez, Miriam
A1 Mariscal, Natividad
A1 Muñoz-Siscart, Ignacio
A1 Díaz-Piñeiro, Dolores
A1 Miguel-Pérez, Irene
A1 Gámez-Leyva, G.
A1 García Bustillo, Álvaro
A1 Martínez-Descalls, A.
K1 Huntington’s disease
K1 Chorea
K1 Mortality
K1 Survival
K1 Lifestyle factors
K1 Enfermedad de Huntington
K1 Huntington's disease
AB Introduction: Despite the wealth of evidence suggesting a protective role of lifestyle factors on Huntington’s disease (HD) onset and progression, their association with mortality has not been extensively studied. The aim of this study was to examine whether lifestyle factors such as caffeine and alcohol consumption, smoking, physical activity level, and Mediterranean diet (MeDi) adherence are associated with mortality among a Spanish cohort of patients with HD with a 9-year surveillance period. Methods: This national study was performed using a nested, observational, longitudinal design. We included subjects diagnosed with HD who participated in the European Huntington’s disease network and Enrol-HD studies. Date of death and baseline lifestyle factor information, demographics, disease severity assessed by the Unified Huntington’s Disease Rating Scale (UHDRS), Problem Behaviours Assessment, total functional capacity (TFC) scores, and comorbidities were collected. Adjusted Cox proportional hazards models were conducted to determine the association of lifestyle factors with mortality. Results: We included 87 patients (52 females) with a mean age of 48.62 ± 14.43 years and CAG repeats of 43.76 ± 5.92. Sixteen deaths were recorded. After correcting for multiple comparisons, deceased patients had higher UHDRS scores at baseline and lower caffeine consumption than live patients. In multivariate Cox regression models, after adjusting for age, CAG repeats, and TFC, mortality risk was associated with lower caffeine consumption (HR 0.13, 95% CI 0.04, 0.45).
PB Elsevier
SN 0213-4853
YR 2025
FD 2025-07
LK https://hdl.handle.net/10259/11909
UL https://hdl.handle.net/10259/11909
LA eng
NO This work was partially supported by the European Hunting-ton Disease Network (EHDN, Seed Fund 338) and by Nutriciaand Advanced Medical Nutrition Fresenius-Kabi Pharmaceu-ticals. Data were analyzed independently by the fundingsources.
DS Repositorio Institucional de la Universidad de Burgos
RD 11-jul-2026