RT info:eu-repo/semantics/article
T1 Impact of Melatonin Supplementation on Sports Performance and Circulating Biomarkers in Highly Trained Athletes: A Systematic Review of Randomized Controlled Trials
A1 Celorrio San Miguel, Ana M.
A1 Roche, Enrique
A1 Herranz López, María
A1 Celorrio San Miguel, Marta
A1 Mielgo Ayuso, Juan
A1 Fernández Lázaro, Diego
K1 Melatonin
K1 Sports supplementation
K1 Sports performance
K1 Safety
K1 Oxidative stress
K1 Antioxidant
K1 Inflammatory response
K1 Health biomarkers
K1 Highly trained athletes
K1 Melatonina
K1 Melatonin
AB Melatonin (N-acetyl-5 methoxytryptamine) is an indolic neurohormone that modulates a variety of physiological functions due to its antioxidant, anti-inflammatory, and immunoregulatory properties. Therefore, the purpose of this study was to critically review the effects of melatonin supplementation in sports performance and circulating biomarkers related to the health status of highly trained athletes. Data were obtained by performing searches in the following three bibliography databases: Web of Science, PubMed, and Scopus. The terms used were “Highly Trained Athletes”, “Melatonin”, and “Sports Performance”, “Health Biomarkers” using “Humans” as a filter. The search update was carried out in February 2024 from original articles published with a controlled trial design. The PRISMA rules, the modified McMaster critical review form for quantitative studies, the PEDro scale, and the Cochrane risk of bias were applied. According to the inclusion and exclusion criteria, 21 articles were selected out of 294 references. The dose of melatonin supplemented in the trials ranged between 5 mg to 100 mg administered before or after exercise. The outcomes showed improvements in antioxidant status and inflammatory response and reversed liver damage and muscle damage. Moderate effects on modulating glycemia, total cholesterol, triglycerides, and creatinine were reported. Promising data were found regarding the potential benefits of melatonin in hematological biomarkers, hormonal responses, and sports performance. Therefore, the true efficiency of melatonin to directly improve sports performance remains to be assessed. Nevertheless, an indirect effect of melatonin supplementation in sports performance could be evaluated through improvements in health biomarkers.
PB MDPI
YR 2024
FD 2024-03
LK https://hdl.handle.net/10259/12170
UL https://hdl.handle.net/10259/12170
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 29-sep-2026