RT info:eu-repo/semantics/conferenceObject
T1 ERK dimerization promotes migration and invasion
A1 Fuente Vivas, Dalia de la
A1 Casar, Berta
A1 Crespo, Piero
K1 Tumores
K1 Tumors
K1 Células cancerosas
K1 Cancer cells
AB Activation of the Ras-ERK signaling cascade is associated with increased metastasis risk inbreast cancer. In the present study. ERK dimerization plays a crucial role in the migrationand invasion of breast tumor cells. ERK dimers bind to the scaffold protein KSR1 toenhance migration. Blocking ERK dimers formation reduced invasion capacity of MCF-7and MDA-231-MB tumors cells. Thus, targeting ERK dimerization could emerge as a validtherapeutic strategy for the treatment of breast cancer.
YR 2021
FD 2021
LK https://hdl.handle.net/10259/12239
UL https://hdl.handle.net/10259/12239
LA eng
NO Póster presentado en: EACR 2021 Virtual Congress, 9-12 June 2021
DS Repositorio Institucional de la Universidad de Burgos
RD 08-oct-2026