RT info:eu-repo/semantics/conferenceObject
T1 Scaffold proteins and cytoskeletal dynamics as modulators of Ras-ERK pathway in cancer
A1 Fuente Vivas, Dalia de la
A1 Casar, Berta
A1 Crespo, Pedro
K1 Citología
K1 Cytology
K1 Bioquímica
K1 Biochemistry
AB An overwhelming body of data unquestionably links the Ras-ERKpathway to the upbringing and progression of human malignancies.About 40% of human cancers harbor activating mutations in proteinsinvolved in this signaling cascade, in particular Ras and Braf. In additionto the main proteins of this signaling pathway, there are severalregulatory proteins known as scaffold proteins, that modulate theintensity, amplitude and duration of ERK signals. Interestingly, it canpropose the scaffold proteins as antitumoral targets. Considering thehypothesis that scaffold proteins interact and regulate the signaltransduction through the Ras-ERK pathway in a coordinated mannerwe try to find out how these interactions are regulated. Ras proteinsare distributed in different types of plasma membrane: microdomainsand endomembranes. We have previously demonstrated thatcompartmentalization dictates Ras utilization of effectors, the intensityof its signals and the biological response of the cells. Cell migration iscritical for many physiological processes and is often misregulated indevelopmental disorders and pathological conditions including cancer.MAPK signaling are known regulators of cytoskeletal dynamics duringcellular processes such as cell adhesion and migration. Our hypothesisis that localized ERK signaling mediated through recently identifiedscaffold proteins and its interactions with the cytoskeleton mayregulate specific cellular responses. Here we propose that associationsamong different scaffold proteins and cytoskeleton will add one furtherdegree of regulation for an already tightly regulated cascade and couldprovide a novel means for manipulating ERK signals, even withtherapeutic purposes.
YR 2018
FD 2018
LK https://hdl.handle.net/10259/12244
UL https://hdl.handle.net/10259/12244
LA eng
NO Póster presentado en: 41 Congreso de la SEBBM, Santander, 10-13 septiembre 2018
DS Repositorio Institucional de la Universidad de Burgos
RD 08-oct-2026