RT info:eu-repo/semantics/conferenceObject
T1 Toxicologial Evaluation of Pristine MXene, PolyPyrrole Functionalized MXene, and MXene-Graphene Hybrids Using Cellular and Computational Models
A1 Fuente Vivas, Dalia de la
A1 Huerta Sainz, Sergio de la
A1 Rodriguez-Vinagre, J.
A1 Palacios Santamaría, David
A1 Aparicio Martínez, Santiago
A1 Gómez Cuadrado, Laura
K1 MXenes
K1 Safe-and-Sustainable-by-Design (SSbD)
K1 New Approach Methodologies (NAMs)
K1 QSAR
K1 3D spheroids
K1 Nanotoxicology
K1 Materiales nanoestructurados
K1 Nanostructured materials
K1 Toxicología
K1 Toxicology
AB Background: MXenes and Graphene possess outstanding physicochemicalproperties (thermal stability, electrical conductivity). They have strongapplication potential in biosensors, conductive ink, and EMI shielding.Challenge: Current (nano)particle regulations present critical gaps, particularlyin human health risk assessment. There is a growing need for Safe byDesign (SbD) aligned evaluation strategies.Aim: Implementing NAMs (in vitro and in silico) to replace animal testing andeffectively bridge the in vitro-in vivo gap in safety assessments.Approach: Step-1 SbD was implemented via chemical hazard identification. Invitro NAMs (static and dynamic 3D spheroids) were compared with 2Dcultures in a multi-tiered approach integrating toxicological profileswith predictive in silico models for mechanistic cellular analysis.Impact: Enables SbD-driven, animal-free predictive toxicology by integratingadvanced 3D NAMs with in silico mechanistic modeling.
YR 2026
FD 2026
LK https://hdl.handle.net/10259/12245
UL https://hdl.handle.net/10259/12245
LA eng
NO Póster presentado a: 23 International Congress ESTIV, Maastricht, 2026, 29 june - 2 july
NO The SAFARI – Safe and Sustainable by Design Graphene/MXenesHybrids project has received funding from the European Union’sHorizon Europe research and innovation programme under GrantAgreement No. 101135965.
DS Repositorio Institucional de la Universidad de Burgos
RD 08-oct-2026