RT info:eu-repo/semantics/bachelorThesis
T1 Puesta a punto de un biosensor para la determinación de analitos de interés en el tratamiento de trastornos depresivos: detección electroquímica de imipramina
A1 Sancho Querol, Sara
A2 Universidad de Burgos. Departamento de Química
K1 Química analítica
K1 Chemistry, Analytic
AB This work reports the development of two different sensors using screen-printed carbon electrodes (SPCEs) for the determination of imipramine (IMP) by differential pulse voltammetry. On one hand, a bare SPCE has been successfully applied to the determination of this compound and, on the other hand, the modification of this SPCE with metallic gold nanoparticles (AuNPs/SPCE) have led to an increase in the sensitivity of IMP determination. Both sensors have been characterized obtaining good capability of detection (14.1 μM and 0.28 μM for SPCE and AuNPs/SPCE, respectively) and reproducibility (4.75 % and 6.87 % for SPCE and AuNPs/SPCE, respectively) values. The specificity of both sensors towards different compounds has been also analyzed and, the developed electrochemical systems have been successfully applied in the determination of IMP in commercial pharmaceutical preparations.
LK http://hdl.handle.net/10259/3533
UL http://hdl.handle.net/10259/3533
LA spa
DS Repositorio Institucional de la Universidad de Burgos
RD 27-abr-2024