RT info:eu-repo/semantics/article
T1 Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles
A1 Guilarte Moreno, Verónica
A1 Castroviejo Fernández, Mª Pilar
A1 García García, Patricia
A1 Fernández Rodríguez, Manuel A.
A1 Sanz Díez, Roberto
K1 Química orgánica
K1 Chemistry, Organic
AB 2,3-Dihaloanilines have been proved as usefulstarting materials for synthesizing 4-halo-1H-indoles. Subsequentor in situ functionalization of the prepared haloindolesallows the access to a wide variety of 2,4- or 2,3,4-regioselectivelyfunctionalized indoles in good overall yields. As noefficient synthetic routes to 2,3-dihaloanilines have been describedin the literature, different approaches to the preparationof these 1,2,3-functionalized aromatic precursors are nowpresented. The most general one involves a Smiles rearrangementfrom the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward andsynthetically useful manner.
PB American Chemical Society
SN 0022-3263
YR 2011
FD 2011-03
LK http://hdl.handle.net/10259/3913
UL http://hdl.handle.net/10259/3913
LA eng
NO Ministerio de Ciencia e Innovacion (MICINN) and FEDER (CTQ2010-15358) and Junta de Castilla y Leon (BU021A09 and GR-172) for financial support. V.G. thanks Ministerio de Educacion y Ciencia for a MEC-FPU predoctoral fellowship. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contracts.
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2025