RT info:eu-repo/semantics/article
T1 Approaches to the Synthesis of 2,3-Dihaloanilines. Useful Precursors of 4-Functionalized-1H-indoles§
A1 Guilarte Moreno, Verónica
A1 Castroviejo Fernández, Mª Pilar
A1 García García, Patricia
A1 Fernández Rodríguez, Manuel A.
A1 Sanz Díez, Roberto
K1 Química orgánica
K1 Chemistry, Organic
AB 2,3-Dihaloanilines have been proved as usefulstarting materials for synthesizing 4-halo-1H-indoles. Subsequentor in situ functionalization of the prepared haloindolesallows the access to a wide variety of 2,4- or 2,3,4-regioselectivelyfunctionalized indoles in good overall yields. As noefficient synthetic routes to 2,3-dihaloanilines have been describedin the literature, different approaches to the preparationof these 1,2,3-functionalized aromatic precursors are nowpresented. The most general one involves a Smiles rearrangementfrom the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward andsynthetically useful manner.
PB American Chemical Society
SN 0022-3263
YR 2011
FD 2011-03
LK http://hdl.handle.net/10259/3913
UL http://hdl.handle.net/10259/3913
LA eng
NO Ministerio de Ciencia e Innovacion (MICINN) and FEDER (CTQ2010-15358) and Junta de Castilla y Leon (BU021A09 and GR-172) for financial support. V.G. thanks Ministerio de Educacion y Ciencia for a MEC-FPU predoctoral fellowship. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contracts.
DS Repositorio Institucional de la Universidad de Burgos
RD 22-nov-2024