RT info:eu-repo/semantics/article
T1 Determination of dichlobenil and its major metabolite (BAM) in onions by PTV–GC–MS using PARAFAC2 and experimental design methodology
A1 Herrero Gutiérrez, Ana
A1 Reguera Alonso, Celia
A1 Ortiz Fernández, Mª Cruz
A1 Sarabia Peinador, Luis Antonio
K1 PTV–GC–MS
K1 D-optimal design
K1 Parallel factor analysis
K1 Desirability function
K1 Dichlobenil
K1 SANCO/12495/2001
K1 Química analítica
K1 Chemistry, Analytic
AB The optimization of a GC–MS analytical procedure which includes derivatization, Quick Easy Cheap Effective Rugged and Safe (QuEChERS) and programmed temperature vaporization (PTV) using design of experiments is performed to determine 2,6-dichlorobenzonitrile (dichlobenil) and 2,6-dichlorobenzamide (BAM) in onions, using 3,5-dichlorobenzonitrile and 2,4-dichlorobenzamide as internal standards. The use of a central composite design and two D-optimal designs, together with the desirability function, makes it possible to significantly reduce the economic, time and environmental cost of the study. The usefulness of PARAFAC2 for solving problems as the interference of unexpected derivatization artifacts unavoidably linked to some derivatization agents, or the presence of coeluents from the complex matrix, which share m/z ratios with the target compounds, is shown. The limits of decision (CCα) of the optimized procedure, 5.00 μg kg− 1 for dichlobenil and 1.55 μg kg− 1 for BAM (α = 0.05), are below the maximum residue limit (MRL) established by the EU for dichlobenil (20 μg kg− 1) in this commodity.
PB Elsevier
SN 0169-7439
YR 2014
FD 2014-04
LK http://hdl.handle.net/10259/4257
UL http://hdl.handle.net/10259/4257
LA eng
NO Ministerio de Economía y Competitividad (CTQ2011-26022) and Juntade Castilla y León (BU108A11-2)
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024