RT info:eu-repo/semantics/article T1 Dealing with the ubiquity of phthalates in the laboratory when determining plasticizers by gas chromatography/mass spectrometry and PARAFAC A1 Oca Casado, Mª Leticia A1 Rubio Martínez, Laura A1 Sarabia Peinador, Luis Antonio A1 Ortiz Fernández, Mª Cruz K1 Phthalates K1 Plasticizers K1 Benzophenone K1 PTV-GC/MS K1 PARAFAC K1 Finger peak K1 Química analítica K1 Chemistry, Analytic AB Determining plasticizers and other additives migrated from plastic materials becomes a hard task when these substances are already present in the laboratory environment. This work dealt with this drawback in the multiresidue determination of four plasticizers (2,6-di-tert-butyl-4-methyl-phenol (BHT), diisobutyl phthalate (DiBP), bis(2-ethylhexyl) adipate (DEHA) and diisononyl phthalate (DiNP)) and a UV stabilizer (benzophenone (BP)) by gas chromatography/mass spectrometry (GC/MS) using DiBP-d4 as internal standard. The ubiquity of DiBP by a non-constant leaching process in the laboratory was detected, which could not guarantee the achievement of a trustworthy quantification. To handle this, the assessment of the level of DiBP in solvent blanks having fixed the probabilities of false non-compliance (α) and false compliance (β) at 0.01 was performed. On the other hand, another special case was that of DiNP, in whose chromatogram finger peaks appear because of an array of possible C9 isomers. PARAFAC, used for the identification and quantification of all the substances, is a useful chemometric tool that enabled a more reliable determination of this analyte since no peak areas were considered but chromatographic and spectral loadings.Since phthalates may migrate from rubber latex items, an evaluation of the existence of matrix effects on the determination of the five analytes was conducted prior to an extraction with hexane from a dummy for infants. As matrix effects were present, the quantification of the compounds under study was performed following the standard addition method using PARAFAC sample loadings as response variable. As a result, the presence of BHT was confirmed, being its concentration equal to 37.87 μg L−1. Calibrations based on PARAFAC yielded the following values for the decision limit (CCα): 1.16 μg L−1 for BHT, 1.34 μg L−1 for BP, 1.84 μg L−1 for DEHA and 51.42 μg L−1 for DiNP(for α = 0.05 and two replicates). PB Elsevier SN 0021-9673 YR 2016 FD 2016-09 LK http://hdl.handle.net/10259/4259 UL http://hdl.handle.net/10259/4259 LA eng NO Ministerio de Economía y Competitividad (CTQ2014-53157-R).M.L. DS Repositorio Institucional de la Universidad de Burgos RD 29-mar-2024