RT info:eu-repo/semantics/article
T1 Brønsted Acid-Catalyzed Cascade Reactions Involving 1,2-Indole Migration
A1 Álvarez Manuel, Estela
A1 Nieto Faza, Olalla .
A1 Silva López, Carlos
A1 Fernández Rodríguez, Manuel A.
A1 Sanz Díez, Roberto
K1 benzofulvenes
K1 Brønsted acid
K1 catalysis
K1 indolemigration
K1 Nazarov cyclization
K1 Chemistry, Organic
K1 Química orgánica
AB A cascade reaction of indoles with propargylic diolsinvolving an unprecedented metal-free 1,2-indole migration onto analkyne is here described. DFT calculations support a mechanismconsisting in a concerted nucleophilic attack of the indole nucleuswith loss of water followed by the 1,2-migration and subsequentNazarov cyclization. This Brønsted acid-catalyzed protocol affordsindole-functionalized benzofulvene derivatives in high yields.
PB Wiley-VCH Verlag
SN 0947-6539
YR 2015
FD 2015-09
LK http://hdl.handle.net/10259/4278
UL http://hdl.handle.net/10259/4278
LA eng
NO Junta de Castilla y León(BU237U13) and Ministerio de Economía y Competitividad (MINECO) and FEDER (CTQ2013-48937-C2-1P and 2-P)
DS Repositorio Institucional de la Universidad de Burgos
RD 11-dic-2024