RT info:eu-repo/semantics/article
T1 ortho-Lithiation Reactions of O-(3,n-Dihalophenyl) N,N-Diethylcarbamates: Synthesis of Dihalosalicylamides and 2,3,n-Trihalophenol Derivatives
A1 Feberero García, Claudia
A1 Velasco, Rocío
A1 Sanz Díez, Roberto
K1 Chemistry, Organic
K1 Química orgánica
AB New dihalosalicylamides and trihalophenol derivatives have been synthesized from easily available O-(3,n-dihalophenyl) N,N-diethylcarbamates by using a directed ortho-metalation (DoM) strategy. The o-lithiation reactions with sBuLi take place regioselectively at the doubly activated C-2 position, which demonstrates the ability of O-carbamates as directed metalating groups. In addition, highly functionalized arylnitriles were accessed from organolithium intermediates by using a tandem transnitrilation/SNAr reaction sequence.
PB Wiley-VCH Verlag
SN 1434-193X
YR 2016
FD 2016-11
LK http://hdl.handle.net/10259/4281
UL http://hdl.handle.net/10259/4281
LA spa
NO Junta de Castilla y León (Consejería deEducación) and FEDER (BU237U13 and BU076U16) as well asthe Ministerio de Economía y Competitividad (MINECO) andFEDER (CTQ2013-48937-C2-1-P)
DS Repositorio Institucional de la Universidad de Burgos
RD 04-dic-2024