RT info:eu-repo/semantics/article
T1 Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells
A1 Pino García, Raquel del
A1 Gerardi, Gisela
A1 Rivero Pérez, Maria Dolores
A1 González San José, Mª Luisa
A1 García Lomillo, Javier
A1 Muñiz Rodríguez, Pilar
K1 Colonic metabolites
K1 Dietary antioxidants
K1 Endothelial function
K1 Hyperglycaemia
K1 Redox signalling
K1 Wine pomace
K1 Food
K1 Biochemistry
K1 Molecular biology
K1 Alimentos
K1 Bioquímica
K1 Biología molecular
AB Dietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial functionimpairment observed in cardiovascular diseases. This study investigates the specificprotective effects of a vegetal seasoning obtained from seedless wine pomace againsthyperglycaemia-induced oxidative damage and dysfunction in human umbilical vein endothelialcells EA.hy926. Non-cytotoxic doses of the bioactive compounds obtained followingin vitro digestion of the seasoning were used as treatments. Digested compounds, especiallycolonic bacterial metabolites, restored a more balanced redox environment, preventedlipid peroxidation and cell membrane damage, ameliorated protein oxidation, and improvedthe balance between endothelial reactive oxygen species and nitric oxide productionin hyperglycaemic cells. Reduction of angiotensin I-converting enzyme activity and genemodulation of superoxide dismutase, haem oxygenase-1, β-nicotinamide adenine dinucleotidephosphate oxidase-4, and endothelial nitric oxide synthase are proposed as themechanisms underlying this protection.These results support the potential benefits of functionalwine pomace seasonings in vascular complications associated with oxidative stress.
PB Elsevier
SN 1756-4646
YR 2016
FD 2016-04
LK http://hdl.handle.net/10259/4297
UL http://hdl.handle.net/10259/4297
LA eng
NO AutonomousGovernment of Castilla y León (Research project BU282U13).The PhD grants of RDPG and JGL (FPU grants AP2010-1933 andFPU12/05494) are funded by the Ministry of Education, Cultureand Sports, Spain.
DS Repositorio Institucional de la Universidad de Burgos
RD 24-nov-2024