RT info:eu-repo/semantics/article
T1 An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
A1 Vallejos Calzada, Saúl
A1 Estévez Bolívar, Pedro Antonio
A1 Ibeas Cortes, Saturnino
A1 García García, Félix Clemente
A1 Serna Arenas, Felipe
A1 García Pérez, José Miguel
K1 sensory materials
K1 chemosensor
K1 fluorogenic sensor
K1 biomolecules
K1 sensing biomolecules
K1 Chemistry
K1 Química
AB The preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for water ‘‘dip-in’’ fluorogenic coenzyme A, cysteine, and glutathione detection by means of host-guest interactions. The sensory material was a membrane with gel-like behaviour, which exhibits a change in fluorescence behaviour upon swelling with a water solution of the target molecules. The membrane follows a “turn-on” pattern, which permits the titration of the abovementioned biomolecules. In this way, the water insoluble sensing motif can be exploited in aqueous media. The sensory motif within the membrane is a chemically anchored piperazinedione-derivative with a weakly bound Hg(II). The response is caused by the displacement of the cation from the membrane due to a stronger complexation with the biomolecules, thus releasing the fluorescent sensory moieties within the membrane
PB MDPI
SN 1424-8220
YR 2012
FD 2012-03
LK http://hdl.handle.net/10259/4359
UL http://hdl.handle.net/10259/4359
LA eng
NO Spanish Ministerio de Ciencia eInnovación—Feder (MAT2011-22544) and by the Junta de Castilla y León (BU001A10-2)
DS Repositorio Institucional de la Universidad de Burgos
RD 22-dic-2024