RT info:eu-repo/semantics/article
T1 Molecular Investigation of Tularemia Outbreaks, Spain, 1997–2008
A1 Ariza Miguel, Jaime
A1 Johansson, Anders
A1 Fernández Natal, Isabel
A1 Martínez Nistal, Carmen
A1 Orduña, Antonio
A1 Rodríguez Ferri, F.
A1 Hernández Pérez, Marta
A1 Rodríguez Lázaro, David
K1 Microbiology
K1 Microbiología
AB Tularemia outbreaks occurred in northwestern Spain in 1997–1998 and 2007–2008 and affected >1,000 persons. We assessed isolates involved in these outbreaks by using pulsed-field gel electrophoresis with 2 restriction enzymes and multilocus variable number tandem repeat analysis of 16 genomic loci of Francisella tularensis, the cause of this disease. Isolates were divided into 3 pulsotypes by pulsed-field gel electrophoresis and 8 allelic profiles by multilocus variable number tandem repeat analysis. Isolates obtained from the second tularemia outbreak had the same genotypes as isolates obtained from the first outbreak. Both outbreaks were caused by genotypes of genetic subclade B.Br:FTNF002–00, which is widely distributed in countries in central and western Europe. Thus, reemergence of tularemia in Spain was not caused by the reintroduction of exotic strains, but probably by persistence of local reservoirs of infection.
PB Centers for Disease Control and Prevention
YR 2014
FD 2014-05
LK http://hdl.handle.net/10259/4411
UL http://hdl.handle.net/10259/4411
LA eng
NO project PEP 2009/1422 of the Junta de Castilla y León (Spain).
DS Repositorio Institucional de la Universidad de Burgos
RD 26-abr-2024